DR. WALTER L. MILLER, M.D.
Medical Practice in San Francisco, CA

6692941, Feb 17, 2004

Feb 15, 1990

07/480745

Walter L. Miller - San Francisco CA
Joseph Augustin Martial - Mill Valley CA
John D. Baxter - San Francisco CA

The Regents of the University of California - Oakland CA

C12N 1500

435 694, 435243, 4352523, 536 2351

A DNA comprising a deoxynucleotide sequence coding for bovine growth hormone is described. A transfer vector and an expression vector containing this DNA and microorganisms transformed by these vectors are also described.

2006011, May 25, 2006

May 20, 2003

10/510593

Himangshu Bose - Sunnyvale CA, US
Vishwanath Lingappa - San Francisco CA, US
Walter Miller - San Francisco CA, US

C12Q 1/68, C07H 21/04, C12P 33/00, C12P 21/06, C07K 14/72

435006000, 435069100, 435320100, 435325000, 530350000, 536023500, 435052000

The steroidogenic acute regulatory protein (StAR), a mitochondrial protein required for stress responses, reproduction, and sexual differentiation of male fetuses is shown to exert its activity transiently at the outer mitochondrial membrane (OMM) rather than in its final resting place in the matrix, and that its OMM residency time and activity are regulated by its speed of mitochondrial import. This may be the first example of a mitochondrial protein exerting its biological activity in a compartment other than that to which it is finally targeted. This unique system which permits steroidogenic cells to initiate and terminate massive levels of steroidogenesis within a few minutes, permitting the rapid regulation of serum steroid hormone concentrations therefore can be manipulated by altering the binding of the leader sequence for the StAR protein to its receptor on the OMM.

5807678, Sep 15, 1998

Mar 23, 1995

8/410540

Walter L. Miller - San Francisco CA
Dong Lin - San Francisco CA
Jerome F. Strauss - Wyndmoor PA

Regents of the University of California - Oakland CA

C12Q 168, C07H 2102, C07H 2104

435 6

Method for diagnosis of congenital lipoid adrenal hyperplasia and for the detection of the presence of a mutated gene for steroidogenesis acute regulatory protein (StAR) by analyzing nucleic acid obtained from a patient. The nucleic acid can be analyzed by restriction fragment length polymorphism analysis, nucleic acid hybridization, or nucleotide sequencing, among other techniques. A mutation may result in premature termination of the protein, or it may result in the StAR gene not being transcribed or translated, or it may result in a change in the amino acid sequence of the StAR gene product.

5939318, Aug 17, 1999

Feb 5, 1996

8/564090

Walter L. Miller - San Francisco CA
Jennifer A. Harikrishna - Kuala Lumpur, MY
Stephen M. Black - Concord CA

Regents of the University of California - Oakland CA

C12N 510, C12N 121, C12N 1562, C12N 1579

435325

Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constructs for production of such enzymes and methods for their use. Methods for their use include cholesterol degradation in vitro or in vivo as well as conversion of cholesterol to other useful steroidal products including pregnenolone.

5547868, Aug 20, 1996

Jun 9, 1993

8/075193

Walter L. Miller - San Francisco CA
Jennifer A. Harikrishna - Selangor, MY
Stephen M. Black - San Francisco CA

Regents of the University of California - Oakland CA

C12N 902, C07K 1480

435189

Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constructs for production of such enzymes and methods for their use. Methods of their use include cholesterol degradation in vitro or in vivo as well as conversion of cholesterol to other useful steroidal products including pregnenolone.

7101981, Sep 5, 2006

Jun 7, 1995

08/487312

Walter L. Miller - San Francisco CA, US
Joseph Augustin Martial - Mill Valley CA, US
John D. Baxter - San Francisco CA, US

Regents of the University of California - Oakland CA

C07K 14/61

530399, 435 694, 43525233, 4241981

Recombinant materials have been obtained which permit the production of bovine growth hormone in.

5045471, Sep 3, 1991

Dec 2, 1986

6/936883

Walter L. Miller - San Francisco CA

The Regents of the University of California - Oakland CA

C12N 1552, C12N 1570, C12N 1574, C12N 1579

4353201

A polynucleotide sequence encoding human P450scc is disclosed along with techniques for utilizing the P450scc expressed by this gene to reduce in vivo cholesterol levles.

4675297, Jun 23, 1987

Sep 14, 1983

6/532107

John D. Baxter - San Francisco CA
Walter L. Miller - San Francisco CA
Joseph A. Martial - Rotheux, BE

The Regents of the University of California - Berkeley CA

C12N 120, C12N 1500, C12N 100, C12P 2100, C12P 2102, C12P 1934, C07H 2104

435253

A DNA sequence encoding bovine prolactin and optionally including condons for the preceding 10 amino acids is used to construct expression systems to obtain recombinant production of these proteins.