DR. WALTER GREGORY SHAKESPEARE, D.O.
Osteopathic Medicine at Broad St, Philadelphia, PA

2014005, Feb 20, 2014

Oct 25, 2013

14/063977

Walter J. Shakespeare - Macungie PA, US
George Kechter - Peoria IL, US
Phillip William Wallace - Bernardsville NJ, US
Matthew J. Schurman - Somerset NJ, US

GLT ACQUISITION CORP. - Irvine CA

A61B 5/1455, A61B 5/145, A61B 5/00, A61B 5/026

600316, 600425

Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.

8219172, Jul 10, 2012

Mar 17, 2006

11/378538

Matthew J. Schurman - Somerset PA, US
Phillip William Wallace - Bernardsville NJ, US
Walter J. Shakespeare - Macungie PA, US
Howard P. Apple - Winter Park FL, US
William Henry Bennett - Bethlehem PA, US

GLT Acquisition Corp. - Irvine CA

A61B 5/1455

600344, 600310, 600316

A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

2012027, Nov 1, 2012

Jul 9, 2012

13/544788

Matthew J. Schurman - Somerset NJ, US
Phillip William Wallace - Bernardsville NJ, US
Walter J. Shakespeare - Macungie PA, US
Howard P. Apple - Winter Park FL, US
William Henry Bennett - Bethlehem PA, US

GLT ACQUISITION CORP. - Irvine CA

A61B 5/1455

600316

A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

8204566, Jun 19, 2012

Aug 2, 2007

11/832721

Matthew J. Schurman - Somerset PA, US
Walter J. Shakespeare - Macungie PA, US

GLT Acquisition Corp. - Irvine CA

A61B 5/1455

600322, 600310, 600316

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

2012020, Aug 16, 2012

Apr 25, 2012

13/456137

Matthew J. Schurman - Somerset NJ, US
Walter J. Shakespeare - Macungie PA, US

GLT ACQUISITION CORP. - Irvine CA

A61B 5/1455

600316, 600322

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

6210546, Apr 3, 2001

Oct 29, 1998

9/182722

David G. Coult - Oley PA
Gustav E. Derkits - New Providence NJ
Walter J. Shakespeare - Macungie PA
Duane D. Wendling - Kutztown PA
Frederick A. Yeagle - Leesport PA

Lucent Technologies Inc. - Murray Hill NJ

C23C 1446, C23C 1450, C23F 100

20419232

Optical components, such as optical semi-isolators, are placed in a fixture that exposes at least a portion of the mounting surface of each optical component when a plasma or ion beam is directed at one side of the fixture, while shielding sensitive surfaces of the optical components (e. g. , an optical element mounted within the frame of the optical component) from direct exposure to the plasma or ion beam. Exposure to the plasma or ion beam removes contaminants (e. g. , metal oxide) that form on the mounting surface during the fabrication of the optical components when the optical element is mounted within its frame using glass solder in a heated oxygenated environment (e. g. , air). By removing enough of the contaminants, the plasma or ion beam cleaning step produces optical components that can be reliably mounted onto substrates, such as the ceramic substrates used in encapsulated laser packages, using flux-less auto-bonding techniques.

8306596, Nov 6, 2012

Sep 22, 2010

12/888318

Matthew J. Schurman - Somerset NJ, US
Walter J. Shakespeare - Macungie PA, US
William Henry Bennett - Bethlehem PA, US

GLT Acquisition Corp. - Irvine CA

A61B 5/1455

600322, 600316

The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

2013006, Mar 7, 2013

Nov 2, 2012

13/668013

Walter J. Shakespeare - Macungie PA, US
William Henry Bennett - Bethlehem PA, US

GLT ACQUISITION CORP. - Irvine CA

A61B 6/02, A61B 5/1455

600316, 600428

The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

8049364, Nov 1, 2011

Jun 4, 2008

12/133048

Walter Jeffrey Shakespeare - Macungie PA, US
Clarence William Crompton - Macungie PA, US

Electrikus, Inc. - Bethlehem PA

H02J 9/00

307 64

A substantially uninterruptible backup power system to provide power to common household appliances comprises a rechargeable battery, a trickle-charging circuit to keep the battery fully charged at all times from the receptacle power, a DC to AC inverter to supply standard AC line voltage from the battery to the lamp, a relay switch, controlled by main power voltage, to switch to the backup system when main power fails, and a timing circuit to optimize a voltage output of the system based on current battery voltage and a desired time period for the voltage output. The system can be set to operate only when the appliance is turned on, which optimizes the current and power required to provide backup power to the appliance for a maximum period of time.