DR. WALEED H HASSANEIN, M.D.
Radiology at Windkist Farm Rd, North Andover, MA
License number
Massachusetts 150970
Category
Radiology
Type
Surgery
Address
Address
30 Windkist Farm Rd, North Andover, MA 01845
Phone
(617) 510-3327
Professional information
Method For Ex-Vivo Organ Care And For Using Lactate As An Indication Of Donor Organ Status
US Patent:
8304181, Nov 6, 2012
Filed:
Apr 25, 2007
Appl. No.:
11/790405
Inventors:
Waleed Hassanein - North Andover MA, US
Tamer Khayal - North Andover MA, US
Paul Lezberg - Westford MA, US
Giovanni Cecere - Needham MA, US
Dennis Sousa - Wakefield MA, US
Elizabeth Hansen - Portsmouth NH, US
Tamer Khayal - North Andover MA, US
Paul Lezberg - Westford MA, US
Giovanni Cecere - Needham MA, US
Dennis Sousa - Wakefield MA, US
Elizabeth Hansen - Portsmouth NH, US
Assignee:
Transmedics, Inc. - Andover MA
International Classification:
A01N 1/02
US Classification:
435 11
Abstract:
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Systems And Methods For Ex-Vivo Organ Care And For Using Lactate As An Indication Of Donor Organ Status
US Patent:
2013007, Mar 28, 2013
Filed:
Aug 16, 2012
Appl. No.:
13/587810
Inventors:
Waleed HASSANEIN - North Andover MA, US
Tamer KHAYAL - North Andover MA, US
Paul LEZBERG - Westford MA, US
Giovanni CECERE - Needham MA, US
Dennis SOUSA - Wakefield MA, US
Elizabeth HANSEN - Portsmouth NH, US
Tamer KHAYAL - North Andover MA, US
Paul LEZBERG - Westford MA, US
Giovanni CECERE - Needham MA, US
Dennis SOUSA - Wakefield MA, US
Elizabeth HANSEN - Portsmouth NH, US
Assignee:
TRANSMEDICS, INC - Palo Alto CA
International Classification:
A01N 1/02
US Classification:
4352841
Abstract:
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Systems For Monitoring And Applying Electrical Currents In An Organ Perfusion System
US Patent:
2008023, Sep 25, 2008
Filed:
Jul 6, 2007
Appl. No.:
11/822495
Inventors:
Waleed Hassanein - North Andover MA, US
Richard Bringham - North Andover MA, US
Robert Havener - Lynnfield MA, US
Vincent Lambert - Salisbury MA, US
Burt Ochs - Andover MA, US
Richard Bringham - North Andover MA, US
Robert Havener - Lynnfield MA, US
Vincent Lambert - Salisbury MA, US
Burt Ochs - Andover MA, US
Assignee:
TransMedics, Inc - Andover MA
International Classification:
A61N 1/04
US Classification:
607 4
Abstract:
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
Systems And Methods For Ex Vivo Lung Care
US Patent:
8420380, Apr 16, 2013
Filed:
Apr 8, 2008
Appl. No.:
12/099717
Inventors:
Robert Fishman - Boston MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - North Andover MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - North Andover MA, US
Assignee:
TransMedics, Inc. - Andover MA
International Classification:
A01N 1/02
US Classification:
4352841, 435 12
Abstract:
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Systems And Methods For Ex Vivo Lung Care
US Patent:
2013015, Jun 20, 2013
Filed:
Feb 12, 2013
Appl. No.:
13/765009
Inventors:
Robert HAVENER - Lynnfield MA, US
Ihab Abdel FATTAH - Andover MA, US
Anas ABDELAZIM - North Andover MA, US
Scott NEWELL - Ipswich MA, US
Tom BISHOP - Wenham MA, US
Tamer I. KHAYAL - North Andover MA, US
Stanley KYI - Andover MA, US
Ron TAYLOR - Chester NH, US
Doug HARRIOTT - Melrose MA, US
Matthew DE REMER - Allston MA, US
Paul MURRAY - Groton MA, US
John SULLIVAN - Groton MA, US
Mark ANDERSON - Danvers MA, US
Richard BRINGHAM - North Andover MA, US
Michael VAN DRIEL - Mirandola, IT
Waleed H. HASSANEIN - North Andover MA, US
Ihab Abdel FATTAH - Andover MA, US
Anas ABDELAZIM - North Andover MA, US
Scott NEWELL - Ipswich MA, US
Tom BISHOP - Wenham MA, US
Tamer I. KHAYAL - North Andover MA, US
Stanley KYI - Andover MA, US
Ron TAYLOR - Chester NH, US
Doug HARRIOTT - Melrose MA, US
Matthew DE REMER - Allston MA, US
Paul MURRAY - Groton MA, US
John SULLIVAN - Groton MA, US
Mark ANDERSON - Danvers MA, US
Richard BRINGHAM - North Andover MA, US
Michael VAN DRIEL - Mirandola, IT
Waleed H. HASSANEIN - North Andover MA, US
Assignee:
TRANSMEDICS, INC - Andover MA
International Classification:
A01N 1/02
US Classification:
435 12
Abstract:
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Organ Care Solution For Ex-Vivo Machine Perfusion Of Donor Lungs
US Patent:
2013001, Jan 10, 2013
Filed:
Apr 13, 2012
Appl. No.:
13/446706
Inventors:
Waleed H. Hassanein - North Andover MA, US
Ihab A. FATTAH - North Andover MA, US
Paul LEZBERG - Westford MA, US
Tamer I. KHAYAL - North Andover MA, US
Robert HAVENER - Lynnfield MA, US
Anas ABDELAZIM - Beachwood OH, US
Ihab A. FATTAH - North Andover MA, US
Paul LEZBERG - Westford MA, US
Tamer I. KHAYAL - North Andover MA, US
Robert HAVENER - Lynnfield MA, US
Anas ABDELAZIM - Beachwood OH, US
International Classification:
A01N 1/02, A61M 31/00
US Classification:
435 12, 4352841, 604500
Abstract:
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
Heart Preservation Chamber
US Patent:
7572622, Aug 11, 2009
Filed:
Aug 14, 2003
Appl. No.:
10/640867
Inventors:
Waleed H. Hassanein - North Andover MA, US
Richard L. Bringham - North Andover MA, US
Richard L. Bringham - North Andover MA, US
Assignee:
TransMedic, Inc. - Andover MA
International Classification:
A01N 1/02
US Classification:
4352841, 435 12
Abstract:
A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.
Systems And Methods For Ex Vivo Organ Care
US Patent:
8535934, Sep 17, 2013
Filed:
Apr 19, 2007
Appl. No.:
11/788865
Inventors:
Waleed Hassanein - North Andover MA, US
Tamer Khayal - North Andover MA, US
Robert Havener - Lynnfield MA, US
Stanley Kyi - Andover MA, US
Ihab Abdel Fattah - North Andover MA, US
Hesham Saleh - S. Lawrence MA, US
Jon Trachtenberg - Andover MA, US
Tamer Khayal - North Andover MA, US
Robert Havener - Lynnfield MA, US
Stanley Kyi - Andover MA, US
Ihab Abdel Fattah - North Andover MA, US
Hesham Saleh - S. Lawrence MA, US
Jon Trachtenberg - Andover MA, US
Assignee:
TransMedics, Inc. - Andover MA
International Classification:
A01N 1/00, A01N 1/02, C12M 1/36, C12M 1/38, C12M 3/00, C12M 1/00, C12M 1/12
US Classification:
4352841, 4352865, 4352866, 4353071, 4352972
Abstract:
The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.
Systems And Methods For Ex Vivo Organ Care
US Patent:
2011013, Jun 9, 2011
Filed:
Sep 28, 2010
Appl. No.:
12/892451
Inventors:
Waleed Hassanein - North Andover MA, US
Tamer Khayal - North Andover MA, US
Robert Havener - Lynnfield MA, US
Stanley Kyi - Andover MA, US
Ihab Abdel Fattah - Andover MA, US
Hesham Saleh - S.Lawrence MA, US
Jon C. Trachtenberg - Andover MA, US
Tamer Khayal - North Andover MA, US
Robert Havener - Lynnfield MA, US
Stanley Kyi - Andover MA, US
Ihab Abdel Fattah - Andover MA, US
Hesham Saleh - S.Lawrence MA, US
Jon C. Trachtenberg - Andover MA, US
Assignee:
TransMedics, Inc. - Andover MA
International Classification:
A01N 1/02
US Classification:
435 12
Abstract:
The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.