Inventors:
Grace Mann - San Mateo CA, US
Naing Aay - San Mateo CA, US
Arlyn Arcalas - South San Francisco CA, US
S. David Brown - San Carlos CA, US
Wai Ki Vicky Chan - San Francisco CA, US
Jeff Chen - San Francisco CA, US
Hongwang Du - Millbrae CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Adam A. Galan - Alameda CA, US
Tai Phat Huynh - New York City NY, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Brian Kane - Lynchburg VA, US
Patrick Kearney - San Francisco CA, US
Byung Gyu Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
James W. Leahy - San Leandro CA, US
Matthew Sangyup Lee - San Bruno CA, US
Gary L. Lewis - San Francisco CA, US
Lisa E. Meyr - Seattle WA, US
Robin Tammie Noguchi - San Bruno CA, US
Michael Pack - San Francisco CA, US
Brian Hugh Ridgway - Belmont CA, US
Xian Shi - San Bruno CA, US
John Woolfrey - Los Altos CA, US
Peiwen Zhou - Palo Alto CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/535, C07D 239/24, C07D 401/10, C07D 413/10
US Classification:
5142358, 544323, 544324, 544333
Abstract:
This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R, R, R, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.