Inventors:
Vu L. Truong - Baltimore MD
Thomas August - Baltimore MD
Kam W. Leong - Ellicot City MD
Assignee:
Johns Hopkins University - Baltimore MD
International Classification:
A61K 4800
US Classification:
514 44, 4353201, 435455, 424468, 424482
Abstract:
A target-specific gene delivery system is made of enzymatically degradable gelatin and nucleic acids (DNA or RNA) microparticles with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method. Targeting ligands can be attached to the microparticle directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the microparticle surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.