VOJO PETER DERETIC
Pilots at Calle Cienega, Placitas, NM
License number
New Mexico A4996671
Issued Date
Feb 2017
Expiration Date
Feb 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
45 Calle Cienega, Placitas, NM 87043
Professional information
Non-Invasive Rapid Diagnostic Test For Infection
US Patent:
7897400, Mar 1, 2011
Filed:
Dec 13, 2007
Appl. No.:
11/955773
Inventors:
Graham Timmins - Albuquerque NM, US
Vojo P. Deretic - Placitas NM, US
Vojo P. Deretic - Placitas NM, US
Assignee:
STC.UNM - Albuquerque NM
International Classification:
G01N 33/00, A61K 31/44
US Classification:
436 63, 514354, 514277, 514183
Abstract:
This invention relates to a test for detecting a (tuberculosis or TB) infection in a patient or subject, specifically a diagnostic test, including a breath test, whereby patients are provided a small dose of an isotopically labeled TB drug, Isoniazid (INH) orally or directly to the lungs of the patient or subject. If TB is present, a TB enzyme mycobacterial peroxidase KatG oxidizes the INH; and KatG specific metabolites, in particular, isotopically labeled nitric oxide (NO), nitrites, nitrates, carbon monoxide (CO) or carbon dioxide converted from carbon monoxide of INH cleavage are measured. Other embodiments relate to a diagnostic breath test for detecting TB utilizing isotopically labeled urea (preferably, carbon-13 labeled urea), alone or in combination with isotopically labeled isoniazid (preferably, nitrogen-15 labeled isoniazid), wherein organism, if present in the patient or subject's lungs (or other tissues), will metabolize the isotopically labeled urea to isotopically labeled carbon dioxide (CO) such that a determination of the residence of , including residence of an isoniazid resistant strain of , may be made.
Diagnosis Of Infection In The Lungs Of Patients
US Patent:
RE44533, Oct 8, 2013
Filed:
May 9, 2012
Appl. No.:
13/467514
Inventors:
Graham Timmins - Albuquerque NM, US
Vojo P. Deretic - Placitas NM, US
Vojo P. Deretic - Placitas NM, US
Assignee:
STC.UNM - Albuquerque NM
International Classification:
A61B 5/08
US Classification:
600532, 600529, 73 233
Abstract:
The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.
Rationally Improved Isoniazid And Ethionamide Derivatives And Activity Through Selective Isotopic Substitution
US Patent:
2013015, Jun 13, 2013
Filed:
Feb 6, 2013
Appl. No.:
13/760605
Inventors:
Graham TIMMINS - Albuquerque NM, US
Sharon Masters - Albuquerque NM, US
Vojo P. Deretic - Placitas NM, US
William Bishai - Towson MD, US
Sharon Masters - Albuquerque NM, US
Vojo P. Deretic - Placitas NM, US
William Bishai - Towson MD, US
Assignee:
The John Hopkins University - Baltimore MD
STC.UNM - Albuquerque NM
STC.UNM - Albuquerque NM
International Classification:
C07D 213/81
US Classification:
514354
Abstract:
The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including
Diagnosis Of Infection In The Lungs Of Patients
US Patent:
7717857, May 18, 2010
Filed:
Apr 25, 2008
Appl. No.:
12/150199
Inventors:
Graham Timmins - Albuquerque NM, US
Vojo P. Deretic - Placitas NM, US
Vojo P. Deretic - Placitas NM, US
Assignee:
STC.UNM - Albuquerque NM
International Classification:
A61B 5/08
US Classification:
600532, 600529, 73 233
Abstract:
The present invention relates to methods for detecting infection and bacterial burden in the lungs of patients who are at risk for infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.
Rationally Improved Isoniazid And Ethionamide Derivatives And Activity Through Selective Isotopic Substitution
US Patent:
8394839, Mar 12, 2013
Filed:
Aug 20, 2008
Appl. No.:
12/674188
Inventors:
Graham Timmins - Albuquerque NM, US
Vojo P Deretic - Placitas NM, US
Vojo P Deretic - Placitas NM, US
Assignee:
STC.UNM - Albuquerque NM
The John Hopkins University - Baltimore MD
The John Hopkins University - Baltimore MD
International Classification:
A61K 31/4409, C07D 213/86
US Classification:
514354, 546324
Abstract:
The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including.