VISHVA MITRA DIXIT
Pharmacy in Los Altos, CA
License number
Michigan 4301052583
Expiration Date
Jan 31, 1998
Category
Pharmacy
Type
CS - 3
Address
Address
Los Altos, CA 94022
Professional information
I-Flice, A Novel Inhibitor Of Tumor Necrosis Factor Receptor-1 And Cd-95 Induced Apoptosis
US Patent:
6680171, Jan 20, 2004
Filed:
Jan 21, 2000
Appl. No.:
09/489155
Inventors:
Jian Ni - Rockville MD
Craig A. Rosen - Laytonsville MD
Vishva M. Dixit - Los Altos Hills CA
Reiner L. Gentz - Silver Spring MD
Joseph J. Kenny - Frederick MD
Craig A. Rosen - Laytonsville MD
Vishva M. Dixit - Los Altos Hills CA
Reiner L. Gentz - Silver Spring MD
Joseph J. Kenny - Frederick MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
The Regents of the University of Michigan - Ann Arbor MI
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07H 2104
US Classification:
435 6, 536 231, 536 235, 435365, 435 691, 435 692, 4352523, 4353201, 530350
Abstract:
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of INFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
Death Domain Containing Receptor 4 Nucleic Acids And Methods
US Patent:
6342363, Jan 29, 2002
Filed:
Jan 27, 1998
Appl. No.:
09/013895
Inventors:
Jian Ni - Rockville MD
Craig A. Rosen - Laytonsville MD
James G. Pan - Ypsilanti MI
Reiner L. Gentz - Silver Spring MD
Vishva M. Dixit - Los Altos Hills CA
Craig A. Rosen - Laytonsville MD
James G. Pan - Ypsilanti MI
Reiner L. Gentz - Silver Spring MD
Vishva M. Dixit - Los Altos Hills CA
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
G01N 3353
US Classification:
435 72, 435 721, 435 691, 4353201, 435325, 4352523, 43525411, 536 231, 536 235, 536 243, 536 2431, 536 234, 530300, 530350
Abstract:
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
Human Irak-2
US Patent:
6653452, Nov 25, 2003
Filed:
Feb 2, 2001
Appl. No.:
09/773753
Inventors:
Jian Ni - Rockville MD
Ping Feng - Gaithersburg MD
Marta Muzio - Milan, IT
Vishva M. Dixit - Los Altos Hills CA
Ping Feng - Gaithersburg MD
Marta Muzio - Milan, IT
Vishva M. Dixit - Los Altos Hills CA
Assignee:
Human Genome Sciences, Inc. - Rockville MD
The Regents of the University of Michigan - Ann Arbor MI
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07K 1600
US Classification:
5303879, 5303871, 5303881
Abstract:
The present invention relates to a novel IRAK-2 protein which is a member of the IL-1 signaling pathway. In particular, isolated nucleic acid molecules are provided encoding the human IRAK-2 protein. IRAK-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting IRAK-2 related disorders and therapeutic methods for treating IRAK-2 related disorders.
Methods For Making Recombinant Proteins Using Apoptosis Inhibitors
US Patent:
2004000, Jan 1, 2004
Filed:
Jun 27, 2003
Appl. No.:
10/607882
Inventors:
Vishva Dixit - Los Altos Hills CA, US
Robert Hamilton - San Carlos CA, US
Jana Goor - Foster City CA, US
Robert Hamilton - San Carlos CA, US
Jana Goor - Foster City CA, US
Assignee:
Genentech, Inc.
International Classification:
C12P021/02, C12N005/06, C07H021/04, C12N009/99
US Classification:
435/069200, 435/184000, 435/320100, 435/325000, 536/023200
Abstract:
The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and markedly improve yield of the desired recombinant proteins.
Raidd, A Novel Death Adaptor Molecule
US Patent:
2003009, May 22, 2003
Filed:
Nov 5, 2002
Appl. No.:
10/287594
Inventors:
Jian Ni - Germantown MD, US
Vishva Dixit - Los Altos Hills CA, US
Vishva Dixit - Los Altos Hills CA, US
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C12Q001/68, C07H021/04, C12N009/64, C12P021/02, C12N005/06
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 435/226000, 536/023200
Abstract:
The present invention relates to a novel molecule involved in the process of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human RAIDD protein and splice variants thereof—referred to as RAIDD-SV1 and RAIDD-SV2. RAIDD polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of RAIDD activity.
Death Domain Containing Receptor-4 Agonist Antibodies And Methods
US Patent:
7060272, Jun 13, 2006
Filed:
Aug 23, 2002
Appl. No.:
10/226318
Inventors:
Jian Ni - Rockville MD, US
Craig A Rosen - Laytonsville MD, US
James G Pan - Ypsilanti MI, US
Reiner L Gentz - Silver Spring MD, US
Vishva M Dixit - Los Altos Hills CA, US
Craig A Rosen - Laytonsville MD, US
James G Pan - Ypsilanti MI, US
Reiner L Gentz - Silver Spring MD, US
Vishva M Dixit - Los Altos Hills CA, US
Assignee:
Human Genome Sciences, Inc. - Rockville MD
The Regents of the University of Michigan - Ann Arbor MI
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 39/395, A61K 51/10, C07K 16/30
US Classification:
4241431, 4241331, 424130, 4241341, 4241381, 4241411, 4241551, 4241741, 4241781, 4241811, 424 149, 530350, 5303871, 5303873, 5303877, 5303881, 53038822, 5303888, 5303891, 5303897, 5303911, 5303913, 5303917
Abstract:
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
Death Domain Containing Receptor 4 Antibodies And Methods
US Patent:
8329179, Dec 11, 2012
Filed:
Jan 18, 2008
Appl. No.:
12/010108
Inventors:
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
James G. Pan - Toronto, CA
Reiner L. Gentz - Belo Horizonte-MG, BR
Vishva M. Dixit - Los Altos Hills CA, US
Craig A. Rosen - Laytonsville MD, US
James G. Pan - Toronto, CA
Reiner L. Gentz - Belo Horizonte-MG, BR
Vishva M. Dixit - Los Altos Hills CA, US
Assignee:
Human Genome Sciences, Inc. - Rockville MD
The Regents of the University of Michigan - Ann Arbor MI
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 39/395, A61K 31/00, C07K 16/30
US Classification:
4241431, 4241331, 4241381, 4241421, 4241351, 4241411, 4241551, 4241741, 4241781, 530350, 514 11, 514 23, 514 75, 514 189, 514 193, 540478
Abstract:
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
Anti-Polyubiquitin Antibodies And Methods Of Use
US Patent:
2013005, Mar 7, 2013
Filed:
Aug 6, 2012
Appl. No.:
13/567919
Inventors:
Robert F. Kelley - Petaluma CA, US
Vishva Dixit - Los Altos CA, US
Marissa L. Matsumoto - Foster City CA, US
Vishva Dixit - Los Altos CA, US
Marissa L. Matsumoto - Foster City CA, US
Assignee:
GENENTECH, INC. - South San Francisco CA
International Classification:
A61K 39/395, C12N 15/63, C12N 5/10, C12N 1/21, C12N 1/15, A61P 25/00, C12P 21/02, G01N 33/566, C07K 16/18, C07K 16/46, A61P 35/00, A61P 21/00, C12N 15/13, C12N 1/19
US Classification:
4241721, 536 2353, 4353201, 435331, 4352523, 43525411, 4352542, 435419, 435 696, 436501, 435 721, 5303898, 435 792, 5303873, 5303917, 5303889
Abstract:
The invention provides anti-polyubiquitin antibodies and methods of using the same.
Anti-Polyubiquitin Antibodies And Methods Of Use
US Patent:
2011025, Oct 20, 2011
Filed:
Apr 14, 2011
Appl. No.:
13/086941
Inventors:
VISHVA DIXIT - LOS ALTOS CA, US
ROBERT F. KELLEY - SAN BRUNO CA, US
MARISSA L. MATSUMOTO - FOSTER CITY CA, US
ROBERT F. KELLEY - SAN BRUNO CA, US
MARISSA L. MATSUMOTO - FOSTER CITY CA, US
Assignee:
GENENTECH, INC. - SOUTH SAN FRANCISCO CA
International Classification:
A61K 39/395, C07H 21/00, A61P 35/00, C12N 5/10, C12P 21/00, C07K 16/18, C12N 15/63
US Classification:
4241341, 5303891, 5303873, 536 2353, 4353201, 435326, 435 696, 4241301
Abstract:
The invention provides anti-polyubiquitin antibodies and methods of using the same.
Copi Molecules And Uses Thereof
US Patent:
2011004, Feb 24, 2011
Filed:
Jun 29, 2010
Appl. No.:
12/826537
Inventors:
David Dornan - Burlingame CA, US
Dorothy French - San Carlos CA, US
Vishva Dixit - Los Altos CA, US
Dorothy French - San Carlos CA, US
Vishva Dixit - Los Altos CA, US
International Classification:
C12Q 1/68, C12Q 1/00, G01N 33/53
US Classification:
435 6, 435 4, 435 71, 435 78
Abstract:
The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.