Inventors:
Cecilia Bastos - South Grafton MA, US
Michael L. Booker - Bridgewater MA, US
Cassandra A. Celatka - Hull MA, US
Jon C. Clardy - Jamaica Plain MA, US
Joseph Cortese - Quincy MA, US
Vishal P. Patel - Washington DC, US
Renato Skerlj - Newton MA, US
Roger C. Wiegand - Wayland MA, US
Dyann F. Wirth - Boston MA, US
International Classification:
A61K 31/5377, C07D 413/04, C07D 409/04, C07D 473/00, C07D 409/14, C07D 471/04, C07D 413/14, A61K 31/4025, A61K 31/4535, A61K 31/4184, A61K 31/4155, A61K 31/496, A61K 31/52, A61K 31/454, A61K 31/437, A61K 31/422, A61P 33/06
US Classification:
51421018, 544146, 548527, 546212, 5483047, 5483657, 544379, 544277, 5483061, 546199, 546118, 548217, 5483054, 548220, 5142315, 514422, 514326, 514394, 514406, 51425213, 51426323, 514322, 514303, 514375
Abstract:
Inhibitors of dihydroorotate dehydrogenase (DHODH) for the enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.