Inventors:
Alan D. Snow - Lynnwood WA, US
Beth P. Nguyen - Bothell WA, US
Gerardo M. Castillo - Seattle WA, US
Virginia J. Sanders - Seattle WA, US
Thomas P. Lake - Snohomish WA, US
Lesley Larsen - Dundein, NZ
Rex T. Weavers - Dundein, NZ
Stephen D. Lorimer - Dundein, NZ
David S. Larsen - Dundein, NZ
David L. Coffen - San Diego CA, US
Charlotte Coffen, legal representative - Belcamp MD, US
Assignee:
Proteotech, Inc. - Kirkland WA
International Classification:
C07C 69/035, C07C 69/21, A61K 31/222, A61K 31/225
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.