Inventors:
Sui Cai - San Diego CA, US
Nilantha Sirisoma - San Diego CA, US
Azra Pervin - Escondido CA, US
John Drewe - Carlsbad CA, US
Shailaja Kasibhatla - San Diego CA, US
Songchun Jiang - San Diego CA, US
Hong Zhang - San Diego CA, US
Chris Pleiman - Holladay UT, US
Vijay Baichwal - Salt Lake City UT, US
John Manfredi - Salt Lake City UT, US
Leena Bhoite - Salt Lake City UT, US
Assignee:
Myriad Genetics, Incorporated - Salt Lake City UT
Cytovia, Inc. - San Diego CA
International Classification:
A61K 31/47, A61K 31/50, A61K 31/517, A61K 31/52, A61K 31/535, A61P 31/00
US Classification:
514234800, 514252020, 514255050, 514263100, 514266100, 514266200, 514311000, 544116000, 544238000, 544258000, 544264000, 544284000, 544293000, 546159000
Abstract:
Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.