DR. VICTOR I. REUS, MD
Psychiatric at Parnassus Ave, San Francisco, CA

6750010, Jun 15, 2004

Nov 24, 1997

08/976560

Nelson B. Freimer - San Francisco CA
Lodewijk Sandkuijl - Delft, NL
Pedro Leon - San Jose, CR
Victor I. Reus - San Francisco CA
Michael Escamilla - San Francisco CA
Lynne Allison McInnes - San Francisco CA
Susan K. Service - Watsonville CA

The Regents of the University of California - Oakland CA
Univerisity of Costa Rica - San Jose

C12Q 168

435 6, 435 912, 536 231, 536 235, 536 242, 536 2431

The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the short arm of chromosome 18 between the telomere and D18S481, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the terminal 5 cM region of the short arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 5 cM region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes. Isolated polynucleotides useful for genetic linkage analysis of BP-I and methods for obtaining such isolated polynucleotides are also described.

6136532, Oct 24, 2000

Nov 24, 1997

8/976752

Nelson B. Freimer - San Francisco CA
Lodewijk Sandkuijl - Delft, NL
Pedro Leon - San Jose, CR
Victor I. Reus - San Francisco CA
Michael Escamilla - San Francisco CA
Lynne Allison McInnes - San Francisco CA

The Regents of the University of California - Oakland CA
The University of Costa Rica - San Jose

C12Q 168, C12P 1934, C07H 2102, C07H 2104

435 6

The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the long arm of chromosome 18 between markers D18S469 and D18S554, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 18q22-q23 region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes. Isolated polynucleotides useful for genetic linkage analysis of BP-I and methods for obtaining such isolated polynucleotides are also described.

2004017, Sep 9, 2004

Jul 28, 2003

10/629313

Nelson Freimer - Santa Monica CA, US
Victor Reus - San Francisco CA, US
Susan Service - Venice CA, US
Lynne McInnes - San Francisco CA, US
Hong Chen - Newton MA, US
Pedro Leon - San Jose, CR
Lodewijk Sandkuijl - Delft, NL
L. Sandkuijl-Schakenbos - Delft, NL

C07K014/705, C12Q001/68, C07H021/04, C12N005/08

530/350000, 435/069100, 435/320100, 435/368000, 435/006000, 536/023500

The present invention relates to the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.