Inventors:
Michael N. Alekshun - Wakefield MA, US
Victor Amoo - Daphne AL, US
Oak K. Kim - Cambridge MA, US
Atul K. Verma - Mansfield MA, US
Assignee:
Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:
A61K 31/5377, C12N 1/14, C12N 1/10, C07H 1/00, A61K 31/4184, C07D 235/18, C07D 413/14, A61K 31/422, C07D 261/18, C07D 413/12, A61K 31/454, C07D 211/32, C07D 263/30, A61K 31/427, C07D 277/04, A61K 31/4709, C07D 215/38, A61K 31/497, A61K 31/4196, C07D 249/08, A61P 31/04, C12N 1/20
US Classification:
5142345, 4352521, 4352541, 4352581, 536 241, 514394, 5483107, 544131, 514378, 548248, 544139, 514322, 546199, 514374, 548236, 514365, 548200, 514314, 546169, 51425505, 544405, 514383, 5482658
Abstract:
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.