DR. VERNE STRUDWICK CAVINESS, M.D.
Neurology at Fruit St, Boston, MA

4961425, Oct 9, 1990

Sep 25, 1987

7/100996

David N. Kennedy - Boston MA
Pauline A. Filipek - Brighton MA
Verne S. Caviness - Charlestown MA

Massachusetts Institute of Technology - Cambridge MA

A61B 5103

128653

A system for automatically determining the outline of a selected anatomical feature or region (e. g. , in a slice of magnetic resonance data) and then making a quantitative determination of a morphometric parameter (such as area or volume) associated with the feature. A volumetric measurement of the feature is made by determining for each slice the areas within the outline for the feature and summing the areas for all the slices; the outlines are based on intensity contours, where the intensity of the contour is intermediate that within and outside of the feature; the intermediate intensity is chosen objectively based on a histogram of intensity levels; interpolation is used to assign contour locations in areas where the intensity of the contour is not present exactly; the accuracy of the outline is improved using an edge-optimization procedure in which the outline is shifted transversely to the location at which an estimate of the derivative (e. g. , the Sobel operator) is a maximum; an alternative technique for choosing the initial outline is to examine the drop or rise in intensity along a radical direction from a starting point within the region of interest and assign the contour to the location at which the difference in intensity reaches a predetermined value; the optimized outline for the first slice of data is saved and used as the initial outline for the adjoining slice, and the procedure of adjusting the outline transversely to the location at which a derivative estimate is a maximum is repeated, and so on, until outlines have been generated for all slices.