Inventors:
Michael J. Mann - Newton MA
Umer Sayeed-Shah - Wappingers Falls NY
Victor Dzau - Newton MA
Lawrence H. Cohn - Chestnut Hill MA
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61B 1900
Abstract:
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e. g. , muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.