ULF R KNOTHE, MD
Medical Practice at Euclid Ave, Cleveland, OH

2005010, May 19, 2005

Feb 20, 2003

10/504652

Melissa Knothe Tate - Cleveland Heights OH, US
Ulf Knothe - Cleveland Heights OH, US

A61F002/28, C12N005/08

623023500, 623023510, 623023760, 623023360, 606077000, 435396000

A composition and method for inducing bone growth and healing is provided. The composition is useful for promoting new bone synthesis, and to enhance the mechanical stability and longevity of orthopaedic implants. The composition includes a bone endogenous material which is used as raw material for the body's natural osteogenic mechanism to synthesize new bone. The composition has a flow phase and a congealed phase. The composition is applied, in the flow phase, within the reamed medullary canal of a long bone prior to insertion of an endoprosthesis. Following insertion of the endoprosthesis, the composition undergoes a phase change to the congealed phase, for example via cross-linking of the bone endogenous material in the composition, to provide a compliant barrier layer in the intra-medullary gap between the implanted endoprosthesis and the medullary canal wall. The resulting barrier layer has a dual mode porosity system, having a first order porosity to accommodate and promote convective diffusion of nutrient species into and through the barrier layer, and a second order porosity to accommodate osteoblastic migration therein without the need for osteoclastic resorption. Osteoblasts synthesize new bone using the barrier layer itself as raw material, essentially osteoconverting the barrier layer into synthesized new bone. In a preferred embodiment, the second order porosity is provided via a rapidly degrading polymer added to the composition, which has a half-life for degradation of 1-60 days.

2013021, Aug 15, 2013

Mar 7, 2011

13/581924

Melissa Knothe Tate - Cleveland Heights OH, US
Ulf Knothe - Cleveland OH, US

A61F 2/28

623 2357

One aspect of the present invention relates to a multilayer surgical membrane. The surgical membrane can include a substantially fluid impermeable outer layer, an inner layer that includes a plurality of fenestrae, and a middle region disposed between the inner and outer layers. The middle region can include at least one channel that extends through the middle region. The middle region can have a first surface in contact with the inner layer. The at least one channel can imbibe fluid under a compressive or tensile load and the fenestrae can deform to exude fluid under the load.