DR. TREVER BIVONA, M.D., PH.D.
Osteopathic Medicine at York Ave, New York, NY
License number
New York 242984
Category
Osteopathic Medicine
Type
Medical Oncology
Address
Address
1233 York Ave APT 6L, New York, NY 10065
Phone
(917) 612-6813
Personal information
See more information about TREVER BIVONA at radaris.comName
Address
Phone
435 30Th St, New York, NY 10016
Professional information
Dr. Trever Bivona, New York NY - MD (Doctor of Medicine)
Specialties:
Oncology, Medical Oncology
Age:
47
Address:
UNITING AGAINST LUNG CANCER
27 Union Sq W SUITE 304, New York 10003
(212) 627-5500 (Phone), (212) 627-7594 (Fax)
27 Union Sq W SUITE 304, New York 10003
(212) 627-5500 (Phone), (212) 627-7594 (Fax)
Languages:
English
Prenyl-Electrostatic Switch, And Methods Of Use
US Patent:
2006008, Apr 20, 2006
Filed:
Apr 19, 2005
Appl. No.:
11/109262
Inventors:
Mark Philips - New York NY, US
Trever Bivona - New York NY, US
Trever Bivona - New York NY, US
International Classification:
A61K 39/395, C07H 21/04, C12P 21/06, A61K 38/48, C07K 14/82
US Classification:
424155100, 514012000, 530350000, 530388800, 435069100, 435320100, 435325000, 536023200
Abstract:
The present invention relates to a method of identifying compounds as candidate drugs for treatment of cancer by providing a cell expressing a GTPase protein that is regulated by a prenyl-electrostatic switch, contacting the cell with compounds to be evaluated, and selecting compounds able to regulate charge at the prenyl-electrostatic switch in the GTPase protein as candidate drugs for treatment of cancer. Also disclosed are methods of treating cancer in a patient. An isolated antibody which binds to a phosphorylated prenyl-electrostatic switch on a K-Ras4B protein is also disclosed, as is a kit for detecting phosphorylation of a prenyl-electrostatic switch in a K-Ras4B protein which includes a labeled antibody and a device to detect the label. Also disclosed is a method of detecting phosphorylation of a prenyl-electrostatic switch on a K-Ras4B protein in a biological sample.