TRACI JENELLE SPEED, M.D., PH.D.
Psychiatric in Baltimore, MD
License number
Maryland 1876
Category
Psychiatric
Type
Psychiatry
Address
Address
600 N. Wolfe St., Baltimore, MD 21287
Phone
(410) 955-6114
Personal information
See more information about TRACI JENELLE SPEED at radaris.comName
Address
Phone
Baltimore, MD
221 Ridgemede Rd, Baltimore, MD 21210
Professional information
Student At The Johns Hopkins University School Of Medicine
Location:
Baltimore, Maryland Area
Industry:
Medical Practice
Dr. Traci J Speed, Baltimore MD - MD (Doctor of Medicine)
Specialties:
Psychiatry
Address:
600 N Wolfe St, Baltimore 21287
(410) 955-6114 (Phone), (410) 614-5914 (Fax)
JOHNS HOPKINS HOSPITAL
600 N Wolfe St, Baltimore 21287
(410) 955-5080 (Phone), (410) 955-1464 (Fax)
(410) 955-6114 (Phone), (410) 614-5914 (Fax)
JOHNS HOPKINS HOSPITAL
600 N Wolfe St, Baltimore 21287
(410) 955-5080 (Phone), (410) 955-1464 (Fax)
Languages:
English
Education:
Medical School
Johns Hopkins University / School of Medicine
Graduated: 2007
Johns Hopkins University / School of Medicine
Graduated: 2007
Agents For Reversing Epigenetic Silencing Of Genes
US Patent:
2010009, Apr 15, 2010
Filed:
Dec 21, 2007
Appl. No.:
12/521109
Inventors:
William G. Nelson - Towson MD, US
Srinivasan Yegnasubramanian - Baltimore MD, US
Xiaohui Lin - Redlands CA, US
Traci J. Speed - Baltimore MD, US
Zachery Reichert - Baltimore MD, US
Srinivasan Yegnasubramanian - Baltimore MD, US
Xiaohui Lin - Redlands CA, US
Traci J. Speed - Baltimore MD, US
Zachery Reichert - Baltimore MD, US
International Classification:
A61K 31/52, C12Q 1/68, A61K 31/4402, A61K 31/517, A61K 31/4164, A61K 31/341, A61K 31/40, A61K 31/415, A61K 31/4155, A61P 35/00, A61P 7/00
US Classification:
5142632, 435 6, 514333, 514342, 51426631, 514393, 514470, 514414, 514361, 514403
Abstract:
The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.