Tongalp H. Tezel
Medical Practice at Muhammad Ali Blvd, Louisville, KY

2013020, Aug 8, 2013

Feb 7, 2011

13/577427

Albena Ivanisevic - Chapel Hill NC, US
Tongalp H. Tezel - Louisville KY, US

A61B 18/00

606 41, 427 21

Surgical instruments having at least one surface modified through formation of polyelectrolyte films and/or nanoparticle deposition thereon to increase adhesion between the surgical instrument and a patient's inner limiting membrane while reducing trauma during surgery are provided. The instrument includes a proximate end operable to be grasped by a surgeon and a distal tip operable to interface with a selected tissue, the distal tip comprising: i. first surface operable to receive at least one electrolyte film; ii. at least one layer of a polyelectrolyte film substantially coating the first surface, the polyelectrolyte film having at least one functional group displaying a charge.

2013017, Jul 11, 2013

May 20, 2011

13/698518

Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Robert A. Mitchell - Louisville KY, US
John O. Trent - Louisville KY, US

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

A61K 39/395, A61K 31/505

4241331, 514256, 4241451

Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.

2010002, Feb 4, 2010

Apr 24, 2007

12/298698

Lucian V. Del Priore - Basking Ridge NJ, US
Henry J. Kaplan - Louisville KY, US
Tongalp Tezel - Louisville KY, US

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

A61K 35/44, C09J 7/02, A61K 9/70, A61F 13/00, A61P 27/02, A61K 47/42, A61K 47/36, A61K 47/34, A61K 47/26, A61P 17/02

424443, 428337, 424 937, 5147723, 5147727, 514774, 514773, 514777, 523118

The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided.

2009004, Feb 19, 2009

Aug 2, 2005

11/659151

Lucian V. Del Priore - Tarrytown NY, US
Tongalp Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

A61K 35/12, A61K 38/16, A61P 17/00, A61P 27/02, A61P 25/00

424 937, 514 12

The invention is directed to compositions and methods for reversing age-related changes in extracellular matrix proteins, particularly the collagen framework of basement membranes of various organs. The invention has particular application to age-related changes that impair Retinal Pigment Epithelium (RPE) cell repopulation of human Bruch's membrane.

2011015, Jun 30, 2011

Feb 25, 2011

13/035272

Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

A61K 39/395, G01N 33/72, A61K 38/18, A61P 27/02

4241721, 436 66, 514 77

The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.

2009005, Feb 26, 2009

Mar 26, 2007

12/294409

Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

G01N 33/72, C12Q 1/00, A61K 38/00, A61K 39/395, A61P 27/00, A61B 5/05, A61B 17/20

436 67, 436 66, 435 4, 514 8, 4241721, 600407, 604 22

The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.

2013008, Apr 4, 2013

Apr 19, 2011

13/642063

Andrea S. Gobin - Louisville KY, US
Tongalp H. Tezel - Louisville KY, US

A61K 45/06, A61K 38/18, A61K 31/78

424 7831

The invention provides hydrogels and methods for their use in treating disorders of the retina such as age-related macular degeneration (AMD).