Inventors:
Scott A. Waldman - Ardmore PA, US
Giovanni Pitari - Philadelphia PA, US
Tong Li - Pennington NJ, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 38/02, A61K 9/00, A61P 1/00, A61K 38/16, A61P 35/00, C12N 1/21, A61K 38/10
US Classification:
424400, 4352523, 514 11, 514 193, 514 214, 514 215, 514 213
Abstract:
Isolated non-pathogenic bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to regulatory sequences operable in bacterium and isolated bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to inducible regulatory sequences operable in bacterium are disclosed. Isolated culture of such bacteria and uses thereof in the prevention and treatment of colonic polyps and/or colorectal cancer as well as methods of activating guanylyl cyclase C in humans are disclosed.