Inventors:
Mark Geraci - Aurora CO, US
Todd Bull - Denver CO, US
Norbert Voelkel - Denver CO, US
Christopher Coldren - Denver CO, US
Assignee:
The Regents of the University of Colorado - Boulder CO
International Classification:
C12Q 1/68
Abstract:
Disclosed are methods to diagnose a patient that has a pulmonary disease, and particularly, pulmonary arterial hypertension, using biomarkers that are differentially regulated in the peripheral blood cells of patients with such disease as compared to individuals that do not have the disease. Also disclosed are methods to diagnose a patient that has idiopathic pulmonary arterial hypertension as compared to pulmonary arterial hypertension associated with secondary causes. Pluralities of nucleotides and antibodies useful in the invention are described. Methods of identifying compounds with the potential to treat pulmonary arterial hypertension (PAH) are also described.