Inventors:
Omid C. Farokhzad - Chestnut Hill MA, US
Frank Alexis - Brighton MA, US
Timothy T. Kuo - Chestnut Hill MA, US
Eric Pridgen - Boston MA, US
Robert S. Langer - Newton MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
International Classification:
A61K 9/127, A61K 9/14, A61K 39/395, A61K 49/00, A61K 38/21, C07K 16/00, C12N 9/96, C07K 14/555, A61P 9/00
US Classification:
424 91, 424491, 4241781, 424 854, 4241301, 4241411, 4241331, 424450, 5303917, 435188, 530351, 977774
Abstract:
The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive drug delivery systems allow for binding to the FcRn receptor and transcytosis into and/or through a cell or cell layer. Inventive systems are useful for delivering therapeutic agents across the endothelium of blood vessels or the epithelium of an organ.