Inventors:
Joseph E. Saavedra - Thurmont MD
Larry K. Keefer - Bethesda MD
Timothy R. Billiar - Pittsburgh PA
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
The University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 3140, A61K 31655, A61K 31535, A61K 31495, A61K 3147, A61K 3128, A61K 31315, A61K 3130, A61K 3120, A61K 31195, A61K 3118, A61K 3104, A61K 3113, A61K 31135
Abstract:
A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tissue from sepsis- or shock-induced injury.