DR. TIMOTHY J MCMAHON, M.D.
Osteopathic Medicine at Roxboro St, Durham, NC
License number
North Carolina 95-01603
Category
Osteopathic Medicine
Type
Pulmonary Disease
Address
Address
4101 N Roxboro St, Durham, NC 27704
Phone
(919) 684-8111
Personal information
See more information about TIMOTHY J MCMAHON at radaris.comName
Address
Phone
5112 Windance Pl, Holly Springs, NC 27540
470 Firetower Rd #B, Elizabeth City, NC 27909
5901 Random Pl, Raleigh, NC 27616
116 Cliffcreek Dr, Holly Springs, NC 27540
109 Collier Pl, Cary, NC 27513
Organization information
See more information about TIMOTHY J MCMAHON at bizstanding.comTimothy J Mcmahon, MD
5324 Mcfarland Rd, Durham, NC 27707
Industry:
Allergist, Anesthesiology, Internist
Professional information
Timothy Joseph McMahon, Durham NC
Specialties:
Pulmonologist
Address:
4101 N Roxboro St, Durham, NC 27704
Education:
Tulane University, School of Medicine - Doctor of Medicine
Duke University Hospital - Fellowship - Pulmonary Disease and Critical Care Medicine (Internal Medicine)
Duke University Hospital - Residency - Internal Medicine
Duke University Hospital - Fellowship - Pulmonary Disease and Critical Care Medicine (Internal Medicine)
Duke University Hospital - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Sub-certificate in Critical Care Medicine (Internal Medicine), American Board of Internal Medicine Sub-certificate in Pulmonary Disease (Internal Medicine)
Use Of An Agent That Restores Tissue Perfusion And Oxygenation
US Patent:
7795219, Sep 14, 2010
Filed:
Jan 7, 2008
Appl. No.:
12/006849
Inventors:
Mark W. Dewhirst - Durham NC, US
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Assignee:
Duke University - Durham NC
International Classification:
A61K 38/00
US Classification:
514 12
Abstract:
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
Use Of An Agent That Restores Tissue Perfusion And Oxygenation
US Patent:
8198241, Jun 12, 2012
Filed:
Jul 30, 2010
Appl. No.:
12/847330
Inventors:
Mark W. Dewhirst - Durham NC, US
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Assignee:
Duke University - Durham NC
International Classification:
A61K 38/00, A61K 33/00
US Classification:
514 121, 424700
Abstract:
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
Use Of An Agent That Restores Tissue Perfusion And Oxygenation
US Patent:
8466110, Jun 18, 2013
Filed:
Apr 18, 2012
Appl. No.:
13/449932
Inventors:
Mark W. Dewhirst - Durham NC, US
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Assignee:
Duke University - Durham NC
International Classification:
A61K 38/00
US Classification:
514 192, 514 133
Abstract:
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
Use Of An Agent That Restores Tissue Perfusion And Oxygenation
US Patent:
7338670, Mar 4, 2008
Filed:
Apr 13, 2006
Appl. No.:
11/404494
Inventors:
Mark W. Dewhirst - Durham NC, US
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Jonathan S. Stamler - Chapel Hill NC, US
Timothy J. McMahon - Durham NC, US
Pierre Sonveaux - Ottignies-Louvain-la-Neuve, BE
Assignee:
Duke University - Durham NC
International Classification:
A61K 9/00, A61K 38/00, C06D 3/00
US Classification:
424700, 514 12, 252372
Abstract:
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
Dr. Timothy J Mcmahon, Durham NC - MD (Doctor of Medicine)
Specialties:
Critical Care Medicine, Pulmonology
Address:
11 Streamley Ct, Durham 27705
106 Research Dr, Durham 27710
(919) 286-6946 (Phone), (919) 416-5847 (Fax)
1 Duke Medical Ctr SUITE 103003, Durham 27710
(800) 266-3853 (Phone), (800) 266-3853 (Fax)
DUKE MEDICINE
4101 N Roxboro St, Durham 27704
(800) 266-3853 (Phone), (919) 681-7292 (Fax)
106 Research Dr, Durham 27710
(919) 286-6946 (Phone), (919) 416-5847 (Fax)
1 Duke Medical Ctr SUITE 103003, Durham 27710
(800) 266-3853 (Phone), (800) 266-3853 (Fax)
DUKE MEDICINE
4101 N Roxboro St, Durham 27704
(800) 266-3853 (Phone), (919) 681-7292 (Fax)
Certifications:
Critical Care Medicine, 2008, Internal Medicine, 1997, Pulmonary Disease, 1999
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Tulane University of Louisiana
Graduated: 1991
Duke University Hospital
Tulane University of Louisiana
Graduated: 1991
Duke University Hospital
Red Blood Cells Loaded With S-Nitrosothiol And Uses Therefor
US Patent:
6916471, Jul 12, 2005
Filed:
Oct 23, 2001
Appl. No.:
10/045603
Inventors:
Jonathan S. Stamler - Chapel Hill NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
C12N005/06
US Classification:
424 9373, 424 937
Abstract:
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal Ometabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal Odelivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.
Measuring Nitric Oxide In Blood Gases And Treatments Based Thereon
US Patent:
2006008, Apr 27, 2006
Filed:
May 27, 2003
Appl. No.:
10/516250
Inventors:
Jonathan Stamler - Chapel Hill NC, US
Timothy McMahon - Durham NC, US
Timothy McMahon - Durham NC, US
International Classification:
G01N 33/50
US Classification:
436068000
Abstract:
Nitric oxide is measured in blood as a marker of tissue blood flow and oxygenation. Where nitric oxide is measured to be below physiological or to be below average, in a patient having a disease associated with oxygen delivery deficiency, nitric oxide is infused alone or with nitrite. Where nitric oxide is measured to be normal, nitrite is infused. The storage time of whole blood or red blood cells is increased and the vasodilator response of outdated or NO depleted whole blood and red blood cells are increased by treatment with nitric oxide and/or nitrite. A patient in need of a transfusion is transfused with whole blood or red blood cells treated to increase vasodilator response therein.
Red Blood Cells Loaded With -Nitrosothiol And Uses Therefor
US Patent:
7329543, Feb 12, 2008
Filed:
Jul 12, 2005
Appl. No.:
11/179349
Inventors:
Jonathan S. Stamler - Chapel Hill NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
C12N 5/06
US Classification:
435372, 424 937, 435325
Abstract:
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal Ometabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal Odelivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.
Red Blood Cells Loaded With S-Nitrosothiol And Uses Therefor
US Patent:
2008022, Sep 11, 2008
Filed:
Feb 5, 2008
Appl. No.:
12/012791
Inventors:
Jonathan S. Stamler - Chapel Hill NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
Joseph Bonaventura - Beaufort NC, US
John R. Pawloski - Raleigh NC, US
Timothy J. McMahon - Durham NC, US
International Classification:
A61K 33/00, A61K 31/195, A61P 9/00
US Classification:
424718, 514562
Abstract:
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal Ometabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal Odelivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.