Inventors:
Marco Cavaleri - Saronno, IT
Luigi Colombo - Malnate, IT
Timothy Henkel - Berwyn PA, US
Daniela Jabes - Cassina Rizzardi, IT
Adriano Malabarba - Buccinasco, IT
Giorgio Mosconi - Malvern PA, US
Martin Stogniew - Blue Bell PA, US
Richard White - Emeryville CA, US
International Classification:
A61K038/16, C07K014/765
US Classification:
514008000, 530322000, 530395000
Abstract:
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue, under conditions where a protein-dalbavancin complex forms, or administering a protein-dalbavancin complex. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.