DR. TIM ALEXANDER FISCHELL, MD
Osteopathic Medicine at Shaffer St, Kalamazoo, MI

2012027, Oct 25, 2012

Apr 22, 2011

13/092363

DAVID R. FISCHELL - FAIR HAVEN NJ, US
TIM A. FISCHELL - KALAMAZOO MI, US

FISCHELL INNOVATIONS LLC - FAIR HAVEN NJ

A61B 18/12

606 41

At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.

7844323, Nov 30, 2010

Jun 22, 2007

11/812827

David R. Fischell - Fair Haven NJ, US
Tim A. Fischell - Kalamazoo MI, US
Jonathan Harwood - Rumson NJ, US
Robert E. Fischell - Dayton MD, US
Steven R. Johnson - Fair Haven NJ, US

Angel Medical Systems, Inc. - Fair Haven NJ

A61B 5/00

600517, 600509

Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

2004000, Jan 8, 2004

Jan 24, 2003

10/351207

Robert Fischell - Dayton MD, US
David Fischell - Fair Haven NJ, US
Tim Fischell - Kalamazoo MI, US
Scott Fischell - Glenelg MD, US

Afmedica, Inc. - Kalamazoo MI

A61F013/00, A61F015/00

602/048000

This invention is an anti-proliferative drug placed onto or within a sterile sheet or mesh that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This mesh or gauze onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL™ absorbable hemostat gauze-like sheet with an anti-proliferative drug such as Rapamycin or Taxol, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions. Another embodiment of this invention is an anti-proliferative drug attached to a bandage that is placed onto a cut in the skin to decrease scar tissue formation. Still another embodiment of the invention is an anti-proliferative drug that is attached to a surgical suture or coated onto a surgical staple both of which are used for connecting human tissues. The suture or staple then being more capable for decreasing cellular proliferation where the suture or staple material passes through the human tissue.

2005013, Jun 23, 2005

Dec 22, 2003

10/741141

Robert Fischell - Dayton MD, US
David Fischell - Fair Haven NJ, US
Tim Fischell - Kalamazoo MI, US

A61B005/04

600509000

The present invention is a system that utilizes optimized high pass or band pass filtering to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system uses either analog or digital high pass filtering having an electrogram voltage reduction of 6 dB at some frequency between 0.05 Hz and 1.0 Hz with less than 6 dB of attenuation at frequencies above 1.0 Hz. and more than 6 dB of attenuation for frequencies below 0.05 Hz. The optimized filter would include attenuation of electric power generation frequencies of either 50 Hz or 60 Hz to reduce electromagnetic interference. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.

2005008, Apr 21, 2005

Jul 8, 2004

10/887272

Ronald Shebuski - Bergland MI, US
Jack Luderer - Kalamazoo MI, US
Tim Fischell - Kalamazoo MI, US

Afmedica, Inc. - Kalamazoo MI

A61K031/4745, A61K031/192, A61F002/00

424426000, 514291000, 514571000, 604500000

The present invention describes various devices and methods wherein a cytostatic antiproliferative drug, either alone or in combination with other drugs, is placed between internal body tissues to prevent the formation of scar tissue and/or adhesions during healing of a wound or surgical site. Specific devices to achieve this administration include, but are not limited to, a permanent implant or a biodegradable material having an attached antiproliferative drug such as sirolimus. These antiproliferative drugs may be combined with other drugs including, but not limited to, antiplatelets, antithrombotics or anticoagulants. The present invention also contemplates methods to a reduce scar tissue and/or adhesions or adhesion formation at an anastomosis site. In particular, a cytostatic antiproliferative drug is administered to an arteriovenous shunt anastomoses in patients having end-stage renal disease.

2012027, Oct 25, 2012

Aug 2, 2011

13/196104

DAVID R. FISCHELL - FAIR HAVEN NJ, US
TIM A. FISCHELL - KALAMAZOO MI, US

FISCHELL INNOVATIONS LLC - FAIR HAVEN NJ

A61M 29/00

604509, 604104

At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

8591495, Nov 26, 2013

Mar 27, 2012

13/431526

Robert E. Fischell - Dayton MD, US
Tim A. Fischell - Kalamazoo MI, US
David R. Fischell - Fairhaven NJ, US

Fischell Innovations, LLC - Dayton MD

A61M 25/00

604526

A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.

2007022, Sep 27, 2007

Mar 24, 2006

11/388161

Robert Fischell - Dayton MD, US
Tim Fischell - Kalamazoo MI, US
Malcolm Foster - Knoxville TN, US

A61F 2/06

623001110

A first aspect of the present invention is an ostial stent positioner that has the form of a wire for most of its length and having a cylinder with expandable legs situated at the positioner's distal end. The cylinder with its attached wire acts as an introducer sheath to introduce a stent delivery system with a stent into the artery that is to be stented. A second aspect of the present invention is a method for accurately placing a stent at the ostium of an artery that would have an ostial stenosis. Examples of such arteries that have ostial stenoses are the right and left main coronary arteries, a saphenous vein graft as used in coronary bypass surgery and the renal arteries. Each of these arteries has an ostium situated at the aorta.

8535294, Sep 17, 2013

Jun 1, 2011

13/150308

Robert E. Fischell - Dayton MD, US
Timothy J. Lynch - Palm Harbor FL, US
Tim A. Fischell - Kalamazoo MI, US

Fischell Innovations LLC - Fair Haven NJ

A61M 25/00

604526, 604524, 604525, 604529

The present invention is a carotid sheath that has a proximal portion that is stiffer than the distal portion of the sheath as a result of the proximal portion having a higher durometer of the outer plastic coating of the sheath's proximal portion with a lower durometer for the plastic coating on the more flexible distal portion of the sheath. Another means to increase the flexibility of the sheath's distal portion compared to a stiffer proximal portion is by having a slightly smaller outside diameter for the outer plastic coating of the distal portion of the sheath. A more flexible distal portion of the sheath allows easier access for angiography, angioplasty or stenting when the sheath is used to access the tortuous path encountered when entering the carotid arteries.