THURMAN WHEELER, M.D.
Neurology in Rochester, NY
License number
New York 235238-1
Category
Neurology
Type
Neuromuscular Medicine
Address
Address
601 Elmwood Ave., Rochester, NY 14642
Phone
(585) 275-6177
Personal information
See more information about THURMAN WHEELER at radaris.comName
Address
Phone
135 Doncaster Rd, Rochester, NY 14623
Organization information
See more information about THURMAN WHEELER at bizstanding.comThurman Wheeler MD
601 Elmwood Ave, Rochester, NY 14642
Industry:
Neurologist
Thurman Marion Wheeler
Professional information
Dr. Thurman M Wheeler, Rochester NY - MD (Doctor of Medicine)
Specialties:
Neuromuscular Medicine, Neuropsychiatry (Neurology)
Address:
601 Elmwood Ave SUITE 645, Rochester 14642
(585) 275-6177 (Phone)
(585) 275-6177 (Phone)
Certifications:
Neurology, 2003, Neuromuscular Medicine, 2008
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of Washington
Graduated: 1995
University of Washington
Graduated: 1995
Thurman Marion Wheeler, Rochester NY
Specialties:
Neurology, Neuromuscular Medicine, Clinical Neurophysiology
Work:
University of Rochester
601 Elmwood Ave, Rochester, NY 14642
601 Elmwood Ave, Rochester, NY 14642
Education:
University of Washington (1995)
Modulation Of Dystrophia Myotonica-Protein Kinase (Dmpk) Expression
US Patent:
2013023, Sep 12, 2013
Filed:
Jul 19, 2011
Appl. No.:
13/811181
Inventors:
C. Frank Bennett - Carlsbad CA, US
Susan M. Freier - San Diego CA, US
Robert A. MacLeod - San Diego CA, US
Sanjay K. Pandey - Encinitas CA, US
Charles A. Thornton - Rochester NY, US
Thurman Wheeler - Rochester NY, US
Seng H. Cheng - Natick MA, US
Andrew Leger - Boston MA, US
Bruce M. Wentworth - Northborough MA, US
Susan M. Freier - San Diego CA, US
Robert A. MacLeod - San Diego CA, US
Sanjay K. Pandey - Encinitas CA, US
Charles A. Thornton - Rochester NY, US
Thurman Wheeler - Rochester NY, US
Seng H. Cheng - Natick MA, US
Andrew Leger - Boston MA, US
Bruce M. Wentworth - Northborough MA, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
ISIS PHARMACEUTICALS, INC. - Carlsbad CA
ISIS PHARMACEUTICALS, INC. - Carlsbad CA
International Classification:
C12N 15/113
US Classification:
514 44 A, 536 245
Abstract:
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
Compositions And Methods Related To Protein Displacement Therapy For Myotonic Distrophy
US Patent:
2010019, Jul 29, 2010
Filed:
Sep 21, 2007
Appl. No.:
12/442354
Inventors:
Charles A. Thornton - Rochester NY, US
Thurman Wheeler - Rochester NY, US
Krzysztof Sobezak - Rochester NY, US
Robert Osborne - Rochester NY, US
Jill Miller - Rockport NY, US
Maurice Swanson - Gainesville FL, US
Thurman Wheeler - Rochester NY, US
Krzysztof Sobezak - Rochester NY, US
Robert Osborne - Rochester NY, US
Jill Miller - Rockport NY, US
Maurice Swanson - Gainesville FL, US
Assignee:
University of Rochester - Rochester NY
University of Florida Research Foundation, Inc. - Gainesville FL
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
A61K 38/14, C12Q 1/68, A61K 31/7088, C12N 5/00, C07H 21/00
US Classification:
514 8, 435 6, 514 44 A, 435325, 536 245
Abstract:
Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)or poly(CCUG)RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.