Inventors:
J. Phillip Bowen - Hull GA
Thomas Phillip Robinson - Durham NC
Tedman Ehlers - Athens GA
David Goldsmith - Atlanta GA
Jack Arbiser - Atlanta GA
Assignee:
The University of Georgia Research Foundation, Inc. - Athens GA
Emory University - Atlanta GA
International Classification:
C07D31100
US Classification:
514460, 514685, 514729, 549401, 568326, 568334
Abstract:
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.