Inventors:
Thomas T. Nguyen - Philadelphia PA
John W. Ellingboe - Ridgewood NJ
Assignee:
American Home Products Corporation - Madison NJ
International Classification:
A61K 3170, C07H 1700
Abstract:
This invention relates to acylated benzylglycosides and a method for their use as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterize by excessive smooth muscle proliferation, such as restenosis. The acylated benzylglycosides of this invention are those of formula I, below: ##STR1## wherein X is ##STR2## R. sup. 1 is H, alkyl having 1 to 6 carbon atoms, chloro, bromo, or alkoxy having 1 to 6 carbon atoms;
R. sup. 2 is H, an acyl group having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl; and
R. sup. 3 is an acyl group having 1 to 8 carbon atoms, benzoyl, substituted benzoyl, alkylsulfonyl having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl;
R. sup. 4, R. sup. 5, R. sup. 6, R. sup. 7, R. sup. 8, and R. sup. 9 are each, independently, an acyl group having 1 to 6 carbon atoms; and
R. sup. 10 and R. sup. 11 are each, independently, an acyl group having 1 to 6 carbon atoms, or the R. sup. 10 and R. sup.