DR. THOMAS SCOTT EDGINGTON, M.D.
Osteopathic Medicine at Avenida De La Playa, La Jolla, CA
License number
California AFE18290
Category
Osteopathic Medicine
Type
General Practice
Address
Address
2362 Avenida De La Playa, La Jolla, CA 92037
Phone
(858) 454-5110
(858) 454-7233 (Fax)
(858) 454-7233 (Fax)
Professional information
Thomas Scott Edgington, La Jolla CA
Specialties:
Pathology, Anatomic Pathology, Immunopathology, General Practice, Cardiovascular Disease
Work:
The Scripps Research Institute
10550 N Torrey Pines Rd, La Jolla, CA 92037
10550 N Torrey Pines Rd, La Jolla, CA 92037
Education:
Stanford University (1957)
Dr. Thomas S Edgington, La Jolla CA - MD (Doctor of Medicine)
Specialties:
Immunopathology
Address:
2362 Avenida De La Playa, La Jolla 92037
(858) 454-5110 (Phone), (858) 454-7233 (Fax)
(858) 454-5110 (Phone), (858) 454-7233 (Fax)
Certifications:
Anatomic Pathology, 1965, Immunopathology, 1983
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Stanford University
Graduated: 1957
Hosp Penn
University Of California-Los Angeles
Scripps Clin Rsch Fdn
Stanford University
Graduated: 1957
Hosp Penn
University Of California-Los Angeles
Scripps Clin Rsch Fdn
Combined Methods And Compositions For Coagulation And Tumor Treatment
US Patent:
6749853, Jun 15, 2004
Filed:
Jan 14, 2000
Appl. No.:
09/483679
Inventors:
Philip E. Thorpe - Cape Elizabeth ME
Thomas S. Edgington - La Jolla CA
Thomas S. Edgington - La Jolla CA
Assignee:
Board of Regents, The University of Texas System - Austin TX
The Scripps Research Institute - La Jolla CA
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 3942
US Classification:
4241821, 4241781, 5303871, 5303873
Abstract:
Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using a bispecific antibody.
Method Of Inhibiting Blood Coagulation In Extracorporeal Circulation By Inhibiting Human Tissue Factor
US Patent:
5437864, Aug 1, 1995
Filed:
Nov 16, 1992
Appl. No.:
7/977281
Inventors:
Thomas S. Edgington - La Jolla CA
Robert W. Colman - Moylan PA
Janos Kappelmayer - Debrecen, HU
L. Henry Edmunds - Bryn Mawr PA
Alvise Bernabei - Philadelphia PA
Robert W. Colman - Moylan PA
Janos Kappelmayer - Debrecen, HU
L. Henry Edmunds - Bryn Mawr PA
Alvise Bernabei - Philadelphia PA
Assignee:
The Scripps Research Institute - La Jolla CA
Trustees of the University of Pennsylvania - Phialdelphia PA
Temple University - Of the Commonwealth Systems of Higher Education - Phialdelphia PA
Trustees of the University of Pennsylvania - Phialdelphia PA
Temple University - Of the Commonwealth Systems of Higher Education - Phialdelphia PA
International Classification:
A61K 39395, G07K 1528
US Classification:
4241451
Abstract:
This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods.
Hybridomas Producing Monoclonal Antibodies Reactive With Human Tissue-Factor Glycoprotein Heavy Chain
US Patent:
5223427, Jun 29, 1993
Filed:
Mar 9, 1988
Appl. No.:
7/165939
Inventors:
Thomas S. Edgington - La Jolla CA
James H. Morrissey - San Diego CA
James H. Morrissey - San Diego CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12N 518, C07K 1528
US Classification:
43524027
Abstract:
Murine hybridomas producing monoclonal antibodies capable of immunoreacting with huTFh and polypeptide analogs are described. Also contemplated are immunologic methods for detecting huTF heavy chain in body fluid, detecting thrombic events in vivo, isolating coagulation factor, and neutralizing VII/VIIa coagulation factor binding in vivo.
Human Tissue Factor Related Dna Segments
US Patent:
5110730, May 5, 1992
Filed:
Jun 25, 1987
Appl. No.:
7/067103
Inventors:
Thomas S. Edgington - La Jolla CA
James H. Morrissey - San Diego CA
James H. Morrissey - San Diego CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12N 1509, C12N 1512, C12N 1586
US Classification:
435 696
Abstract:
DNA segments include DNA sequences defining a structural gene coding for a human tissue factor heavy chain protein and a precursor form of that protein are disclosed. Recombinant DNA molecules capable of expressing a human tissue factor heavy chain protein are also disclosed. Further disclosed are human tissue factor heavy chain binding site polypeptide analogs as well as methods for their use.
Kits And Methods For The Specific Coagulation Of Vasculature
US Patent:
6036955, Mar 14, 2000
Filed:
Jun 7, 1995
Appl. No.:
8/479727
Inventors:
Philip E. Thorpe - Dallas TX
Thomas S. Edgington - La Jolla CA
Thomas S. Edgington - La Jolla CA
Assignee:
The Scripps Research Institute - La Jolla CA
Board of Regents, The University of Texas System - Austin TX
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K 39395
US Classification:
4241361
Abstract:
Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using a bispecific antibody.
Human Tissue Factor Related Dna Segments Polypeptides And Antibodies
US Patent:
6001978, Dec 14, 1999
Filed:
Apr 22, 1997
Appl. No.:
8/844806
Inventors:
Thomas S. Edgington - La Jolla CA
James H. Morrissey - Oklahoma City OK
James H. Morrissey - Oklahoma City OK
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07K 1636, C07K 1646
US Classification:
5303913
Abstract:
DNA segments that include DNA sequences defining a structural gene coding for a human tissue factor heavy chain protein and a precursor form of that protein are disclosed. Recombinant DNA molecules capable of expressing a human tissue factor heavy chain protein are also disclosed. Further disclosed are human tissue factor heavy chain binding site polypeptide analogs as well as methods for their use.
Inhibition Of Mac-1 Receptor Binding To Fibrinogen Using D.sub.30 Homologs
US Patent:
5473051, Dec 5, 1995
Filed:
Jul 18, 1991
Appl. No.:
7/734296
Inventors:
Dario C. Altieri - La Jolla CA
Edward F. Plow - San Diego CA
Thomas S. Edgington - La Jolla CA
Edward F. Plow - San Diego CA
Thomas S. Edgington - La Jolla CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07K 1475, C07K 706
US Classification:
530382
Abstract:
The present invention contemplates therapeutic compositions containing a D. sub. 30 homolog capable of binding to the Mac-1 receptor D. sub. 30 binding site and inhibiting fibrinogen binding to the Mac-1 receptor via the D. sub. 30 binding site, Methods of inhibiting Mac-1 receptor binding to any Mac-1 ligand and methods of inhibiting Mac-1 receptor mediated inflammation within a patient by administering a D. sub. 30 homolog are also contemplated,.
Diagnostic Assay For The Presence Of Apolipoproteins Associated With Plasma High Density Lipoproteins
US Patent:
4677057, Jun 30, 1987
Filed:
Mar 11, 1985
Appl. No.:
6/710038
Inventors:
Linda K. Curtiss - San Diego CA
Thomas S. Edgington - La Jolla CA
Thomas S. Edgington - La Jolla CA
Assignee:
Scripps Clinic and Research Foundation - La Jolla CA
International Classification:
G01N 3353, G01N 33543, C12N 1500, C12N 500
US Classification:
435 7
Abstract:
Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-II, are described as are their methods of use and articles of manufacture containing them.