THOMAS RALPH KLEYMAN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD041025E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15261
Professional information
Thomas R Kleyman, Pittsburgh PA
Specialties:
Nephrologist
Address:
3550 Terrace St, Pittsburgh, PA 15213
Education:
Washington University, School of Medicine - Doctor of Medicine
New York Presbyterian Hospital/Weill Cornell Medical Center - Fellowship - Nephrology (Internal Medicine)
New York Presbyterian Hospital/Weill Cornell Medical Center - Residency - Internal Medicine
New York Presbyterian Hospital/Weill Cornell Medical Center - Fellowship - Nephrology (Internal Medicine)
New York Presbyterian Hospital/Weill Cornell Medical Center - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Nephrology (Internal Medicine)
Thomas Kleyman, Philadelphia PA
Work:
Clinical Health Care Associates NJ PC
4126 Walnut St, Philadelphia, PA 19104 Clinical Health Care Associates NJ PC
3400 Spruce St, Philadelphia, PA 19175 Clinical Health Care Associates NJ PC
39th Market Sts, Philadelphia, PA 19104 Univ. of Pittsburgh Physicians
120 Lytton Ave, Pittsburgh, PA 15213
4126 Walnut St, Philadelphia, PA 19104 Clinical Health Care Associates NJ PC
3400 Spruce St, Philadelphia, PA 19175 Clinical Health Care Associates NJ PC
39th Market Sts, Philadelphia, PA 19104 Univ. of Pittsburgh Physicians
120 Lytton Ave, Pittsburgh, PA 15213
Dr. Thomas R Kleyman - MD (Doctor of Medicine)
Hospitals:
3550 Terrace St STE A-919, Pittsburgh 15213
UNIV OF PTTSBURG SCHL MEDICINE
3550 Terrace St, Pittsburgh 15213
3550 Terrace St STE A-919, Pittsburgh 15213
UNIV OF PTTSBURG SCHL MEDICINE
3550 Terrace St, Pittsburgh 15213
UNIV OF PTTSBURG SCHL MEDICINE
3550 Terrace St, Pittsburgh 15213
3550 Terrace St STE A-919, Pittsburgh 15213
UNIV OF PTTSBURG SCHL MEDICINE
3550 Terrace St, Pittsburgh 15213
Education:
Medical Schools
Washington Center / School of Medicine
Graduated: 1978
Washington Center / School of Medicine
Graduated: 1978
Dr. Thomas R Kleyman - MD (Doctor of Medicine)
Hospitals:
UPMC Kidney Clinic
120 Lytton Ave STE 300, Pittsburgh 15213
9 South Ct, Pittsburgh 15239
UPMC Kidney Clinic
120 Lytton Ave STE 300, Pittsburgh 15213
9 South Ct, Pittsburgh 15239
120 Lytton Ave STE 300, Pittsburgh 15213
9 South Ct, Pittsburgh 15239
UPMC Kidney Clinic
120 Lytton Ave STE 300, Pittsburgh 15213
9 South Ct, Pittsburgh 15239
Education:
Medical Schools
Washington University St Louis
Graduated: 1978
Washington University St Louis
Graduated: 1978
Epithelial Sodium Channel Inhibiting Agents And Uses Therefor
US Patent:
2007014, Jun 28, 2007
Filed:
Dec 12, 2006
Appl. No.:
11/637568
Inventors:
James Bruns - Imperial PA, US
Marcelo Carattino - Pittsburgh PA, US
Rebecca Hughey - McDonald PA, US
Thomas Kleyman - Pittsburgh PA, US
Shaohu Sheng - Cheswick PA, US
Marcelo Carattino - Pittsburgh PA, US
Rebecca Hughey - McDonald PA, US
Thomas Kleyman - Pittsburgh PA, US
Shaohu Sheng - Cheswick PA, US
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 38/17, C07K 14/47
US Classification:
514012000, 530324000
Abstract:
Disclosed herein are peptide cleavage products, generated during natural processing of epithelial sodium channel α- and γ-subunits and their use in inhibiting epithelial sodium channel activity. Also disclosed herein are polypeptide and polypeptide analog derivatives of those agents. These epithelial sodium channel-inhibitory agents may be formulated into a drug product for, without limitation, inhibition of epithelial sodium channel function in a patient's airway, useful in treating, among other diseases or conditions: hypertension, congestive heart failure, cirrhosis, nephrotic syndrome, hypokalemia, cystic fibrosis, chronic pulmonary obstructive diseases, such as chronic bronchitis, asthma and bronchiectasis. A method of testing the activity of an epithelial sodium channel-inhibitory agent also is provided.