THOMAS MASON SMITH
Engineering in Norristown, PA
License number
Pennsylvania ET001531
Category
Engineers
Type
Engineer in Training
Address
Address
Norristown, PA 19403
Personal information
See more information about THOMAS MASON SMITH at radaris.comName
Address
Phone
50 S Penn St, Hatboro, PA 19040
508 2Nd St, Peckville, PA 18452
50 Mapleview Dr, Honesdale, PA 18431
512 N Centre St APT 2I, Pottsville, PA 17901
507 N 7Th Ave, Royersford, PA 19468
Professional information
See more information about THOMAS MASON SMITH at trustoria.com
Methods For Purifying Antibodies Using Ceramic Hydroxyapatite
Methods For Purifying Antibodies Using Ceramic Hydroxyapatite
US Patent:
2010023, Sep 16, 2010
Filed:
Jun 13, 2007
Appl. No.:
12/304782
Inventors:
Gregory J. Mazzola - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
International Classification:
C07K 1/22, C07K 16/00
US Classification:
5303881, 5303871
Abstract:
This invention relates to the purification of monoclonal antibodies from mammalian cell culture fluid utilizing sequential, orthogonal chromatography and filtration techniques resulting in material of high purity and quality that is suitable for human administration. The method involves capturing an IgG product using immobilized protein A affinity chromatography, followed by at least one ion exchange technique prior to adsorbing the IgG to hydroxyapatite and selectively eluting the product in a single isocratic step to achieve purification from impurities and simultaneously reducing multiple types of impurities including but not limited to IgG aggregates, residual protein A, non-IgG proteins, host cell proteins, viral particles, and DNA
Antibody Purification
Antibody Purification
US Patent:
RE40070, Feb 19, 2008
Filed:
May 27, 2005
Appl. No.:
11/140525
Inventors:
Paula Shadle - Lafayette CA, US
John C. Erickson - Research Triangle Park NC, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
John C. Erickson - Research Triangle Park NC, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
B01D 15/08, B01D 15/32, C07K 16/00, C07K 1/00
US Classification:
210635, 210656, 5303871, 5303905, 530413, 530417
Abstract:
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins. The questions raised in reexamination request, 09/006,966 filed Mar. 12, 2004 have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U. S. C. 307 as provided in 37 CFR 1. 570()().
Antibody Purification
Antibody Purification
US Patent:
RE41555, Aug 24, 2010
Filed:
May 18, 2007
Appl. No.:
11/804729
Inventors:
Paula Shadle - Lafayette CA, US
John C. Erickson - King of Prussia PA, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
John C. Erickson - King of Prussia PA, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
Assignee:
Glaxosmithkline LLC - Philadelphia PA
International Classification:
B01D 15/08, B01D 15/32, C07K 16/00, C07K 1/00
US Classification:
210635, 210656, 5303871, 5303905, 530413, 530417
Abstract:
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecular proteins.
Antibody Purification
Antibody Purification
US Patent:
RE41595, Aug 31, 2010
Filed:
Mar 13, 2009
Appl. No.:
12/403799
Inventors:
Paul J. Shandle - Lafayette CA, US
John C. Erickson - King of Prussia PA, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
John C. Erickson - King of Prussia PA, US
Robert G. Scott - King of Prussia PA, US
Thomas M. Smith - King of Prussia PA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
B01D 15/08, B01D 15/32, C07K 16/00, C07K 1/00
US Classification:
210635, 210656, 5303871, 5303905, 530413, 530417
Abstract:
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins.