Inventors:
John N. Feder - Belle Mead NJ, US
Thomas C. Nelson - Lawrenceville NJ, US
Chandra S. Ramanathan - Ringoes NJ, US
Rolf-Peter Ryseck - Ewing NJ, US
Michael G. Kornacker - Princeton NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12N 1/68, G01N 33/48, C07K 14/705
US Classification:
435 6, 436 63, 436 64, 436 94
Abstract:
The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.