Inventors:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY, US
Catherine FORSTER - Wayne PA, US
Thomas L. NICKOLAS - New York NY, US
Neal PARAGAS - New York NY, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
International Classification:
G01N 33/68
Abstract:
The present invention is directed to methods for diagnosis of urosepsis, sepsis, and urinary tract infections (UTIs), and to methods for distinguishing between urosepsis, sepsis of other origins, and localized UTIs. In some aspects, the diagnostic methods of the invention are based on determining whether a bodily fluid sample, such as urine sample, contains an amount of NGAL protein that exceeds or is less than a certain threshold level, or that falls within a certain range. The present invention also provides diagnostic kits.