THOMAS LEE CASAVANT
Pilots at Grant St, Iowa City, IA

5613136, Mar 18, 1997

Oct 29, 1993

8/143368

Thomas L. Casavant - Iowa City IA
Samuel A. Fineberg - Sunnyvale CA
Devin L. Bright - Palatine IL
Subbiah Sundaram - Los Angeles CA
Michelle L. Roderick - Fort Collins CO

University of Iowa Research Foundation - Iowa City IA

G06F 1500

395800

A method and an apparatus for reconciling communication and locality by enabling a user/programmer to write programs in an extended procedural language which explicitly manipulate locality. The multiprocessor includes a plurality of processing elements connected to each other each processing element having a unique address and including a central processing unit for executing local CPU code and reading and writing local data and a locality manager for controlling data movement between processing elements which are cooperating on a single task by executing local locality manager code which indicates when shared data can be released and when non-local data is requested.

5442797, Aug 15, 1995

Dec 4, 1991

7/800530

Thomas L. Casavant - Iowa City IA
Samuel A. Fineberg - Iowa City IA

G06F 1300

395800

A method and an apparatus for reconciling communication and locality by enabling a user/programmer to write programs in an extended procedural language which explicitly manipulate locality. The multiprocessor includes a plurality of processing elements connected to each other each processing element having a unique address and including a central processing unit for executing local CPU code and reading and writing local data and a locality manager for controlling data movement between processing elements which are cooperating on a single task by executing local locality manager code which indicates when shared data can be released and when non-local data is requested.

5904822, May 18, 1999

Nov 13, 1996

8/748589

Thomas L. Casavant - Iowa City IA

The University of Iowa Research Foundation - Iowa City IA

G01N27/26

204461

This invention relates to a system and methods for the straightening an electrophoresis gel image in the vertical and horizontal directions, and for analyzing a straightened gel image. The system includes an input unit for receiving raw data from the electrophoresis gel, a straightening unit for providing a straightened gel image, an output unit for portraying the raw data from the electrophoresis gel and the straightened gel image, and a an analyzing unit for analyzing the data portrayed in the straightened gel image. The system features a dye boost feature for boosting the intensity of bands, filtering means for modifying the gel image, and a genotype editing feature for editing the results of an automatic gel analysis. The system allows for manual and automatic analysis of the straightened gel image according to a specified set of analysis parameters providing a range of analysis stringency levels.

2005027, Dec 15, 2005

May 3, 2005

11/121301

Paul McCray - Iowa City IA, US
Brian Schutte - Iowa City IA, US
Hong Jia - Iowa City IA, US
Thomas Casavant - Iowa City IA, US
Michael Welsh - Riverside IA, US

A61K038/17, C07K014/47, C07H021/04, C12N015/86

435069100, 514012000, 530324000, 435320100, 435456000, 435325000, 536023500

The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 β-defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the β-defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents or antibiotics.

2003017, Sep 18, 2003

Sep 23, 2002

10/252734

Paul McCray - Iowa City IA, US
Brian Schutte - Iowa City IA, US
Hong Jia - Iowa City IA, US
Thomas Casavant - Iowa City IA, US
Michael Welsh - Riverside IA, US

A61K038/17, C12P021/02, C12N005/06, C07K014/47, C07H021/04, C12N005/08, C12N015/867

530/350000, 435/069100, 435/069300, 435/456000, 435/320100, 435/325000, 435/372000, 514/012000, 536/023500

The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 -defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the -defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents or antibiotics.

7332591, Feb 19, 2008

Dec 21, 2004

11/019081

Val C. Sheffield - Iowa City IA, US
Edwin Stone - Iowa City IA, US
Thomas Casavant - Iowa City IA, US
Terry Braun - Iowa City IA, US
Darryl Nishimura - Coralville IA, US

The University of Iowa Research Foundation - Iowa City IA

C07H 21/04

536 231, 536 235, 536 241

The present invention relates to the designation of ADP-ribosylation factor-like 6 as the BBS3 gene, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.

2011010, May 5, 2011

Oct 29, 2010

12/915768

Abbot F. Clark - Fort Worth TX, US
Edwin M. Stone - Iowa City IA, US
Val C. Sheffield - Iowa City IA, US
John Fingert - Iowa City IA, US
Thomas L. Casavant - Iowa City IA, US
Todd Scheetz - Iowa City IA, US
Terry Braun - Iowa City IA, US
A. Jason Grundstad - Oak Lawn IL, US

ALCON RESEARCH, LTD. - Fort Worth TX
IOWA RESEARCH FOUNDATION, UNIVERSITY OF - Iowa City IA

A61K 39/395, G01N 33/50, C40B 40/06, A61P 27/02

4241331, 436 94, 506 16

The invention provides genes and polymorphisms associated with AMD, and methods for diagnosing an increased risk of AMD in a patient who has at least one of the AMD-associated polymorphisms as provided.