THOMAS L WHITSETT, MD
Osteopathic Medicine at 10 St, Oklahoma City, OK

5503850, Apr 2, 1996

Dec 9, 1994

8/352975

Edgar A. O'Rear - Norman OK
Philip D. Nguyen - Norman OK
Arthur E. Johnson - Norman OK
Eugene S. Patterson - Oklahoma City OK
Thomas L. Whitsett - Oklahoma City OK

Research Corporation Technologies, Inc. - Tucson AZ

A61K 9127

424450

A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intravenous injection of a composition comprising a plurality of microcapsules comprising a plasminogen activator core surrounded by a controlled release semi-permeable layer.