THOMAS L RICKETTS
Engineering in Halifax, MA
License number
Massachusetts 21306
Issued Date
Jun 2, 2006
Type
Engineer in Training
Address
Address
Halifax, MA 02338
Professional information
Bioadhesive Polymers With Catechol Functionality
US Patent:
2005020, Sep 15, 2005
Filed:
Dec 9, 2004
Appl. No.:
11/009327
Inventors:
Marcus Schestopol - Providence RI, US
Jules Jacob - Taunton MA, US
Ryan Donnelly - Quincy MA, US
Thomas Ricketts - Halifax MA, US
Avinash Nangia - Wrentham MA, US
Edith Mathiowitz - Brookline MA, US
Ze'ev Shaked - San Antonio TX, US
Jules Jacob - Taunton MA, US
Ryan Donnelly - Quincy MA, US
Thomas Ricketts - Halifax MA, US
Avinash Nangia - Wrentham MA, US
Edith Mathiowitz - Brookline MA, US
Ze'ev Shaked - San Antonio TX, US
International Classification:
A61K031/74
US Classification:
424078270
Abstract:
Polymers with improved bioadhesive properties and methods for improving bioadhesion of polymers have been developed. A compound containing an aromatic group which contains one or more hydroxyl groups is grafted onto a polymer or coupled to individual monomers. In one embodiment, the polymer is a biodegradable polymer. In another embodiment, the monomers may be polymerized to form any type of polymer, including biodegradable and non-biodegradable polymers. In some embodiments, the polymer is a hydrophobic polymer. In the preferred embodiment, the aromatic compound is catechol or a derivative thereof and the polymer contains reactive functional groups. In the most preferred embodiment, the polymer is a polyanhydride and the aromatic compound is the catechol derivative, DOPA. These materials display bioadhesive properties superior to conventional bioadhesives used in therapeutic and diagnostic applications. These bioadhesive materials can be used to fabricate new drug delivery or diagnostic systems with increased residence time at tissue surfaces, and consequently increase the bioavailability of a drug or a diagnostic agent. In a preferred embodiment, the bioadhesive material is a coating on a controlled release oral dosage formulation and/or forms a matrix in an oral dosage formulation.
Multi-Layer Tablets And Bioadhesive Dosage Forms
US Patent:
2008031, Dec 18, 2008
Filed:
Aug 29, 2005
Appl. No.:
11/661541
Inventors:
Avinash Nangia - Sharon MA, US
Jules Jacob - Taunion MA, US
Edith Mathiowitz - Brookline MA, US
Thomas Ricketts - Halifax MA, US
Mark R. Kreitz - Tacoma WA, US
Jules Jacob - Taunion MA, US
Edith Mathiowitz - Brookline MA, US
Thomas Ricketts - Halifax MA, US
Mark R. Kreitz - Tacoma WA, US
International Classification:
A61K 9/52, A61K 9/32, A61K 9/48, A61K 9/24
US Classification:
424457, 424482, 424463, 424472
Abstract:
Bioadhesives coatings increase the gastrointestinal retention time of orally-ingested medicaments. Certain bioadhesive coatings producing a fracture strength of at least 100 N/m, as measured on rat intestine, when applied to at least one surface of a pharmaceutical dosage form for oral delivery of a drug, result in a gastrointestinal retention time of at least 4 hours in a fed beagle dog model, during which the drug is released from the dosage form.Multi-layer tablets, particularly those including hydrophobic excipients, are useful in administering hygroscopic and/or deliquescent drugs. In addition, varying the amount of drug in multi-layer tablets allows the release rate of the drug to be controlled.