Thomas L Olson
Plumbers in Salt Lake City, UT
License number
Utah 151296-5509
Issued Date
Sep 19, 1985
Expiration Date
Apr 30, 1986
Category
Plumber
Type
Apprentice Plumber
Address
Address
Salt Lake City, UT
Professional information
Actin Mutations In Dilated Cardiomyopathy, A Heritable Form Of Heart Failure
US Patent:
6063576, May 16, 2000
Filed:
Jun 29, 1998
Appl. No.:
9/106217
Inventors:
Mark T. Keating - Salt Lake City UT
Thomas M. Olson - Salt Lake City UT
Thomas M. Olson - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 168
US Classification:
435 6
Abstract:
Two mutations in the human cardiac actin gene are disclosed which have been associated with idiopathic dilated cardiomyopathy (IDC) in two families. These mutations cosegregate with IDC in the two families. Both mutations affect universally conserved amino acids in domains of actin that attach to Z bands and intercalated discs. Analysis of the cardiac actin gene can be used to determine the presence in a patient of IDC resulting from mutations in this gene. Such analysis is useful in the diagnosis and prognosis of the disease in patients with mutations in this gene.