Thomas Kent Smith
Engineers in Winston Salem, NC
License number
Colorado 25300
Issued Date
Nov 20, 1987
Renew Date
Aug 28, 1992
Expiration Date
Aug 28, 1992
Type
Professional Engineer
Address
Address
900 Ncnb Plz, Winston Salem, NC 27101
Professional information
Control Of Blood Flow In Skin, Subcutaneous Tissue And Muscle By Botulinum Toxin, Snare Protein Mediating Substances, And Alpha Adrenergic Agents By Either Injection Of Transdermal Delivery Systems
US Patent:
2011014, Jun 16, 2011
Filed:
Dec 16, 2009
Appl. No.:
12/654281
Inventors:
L. Andrew Koman - Winston-Salem NC, US
Thomas Smith - Winston-Salem NC, US
Thomas Smith - Winston-Salem NC, US
International Classification:
A61K 39/08, A61P 17/00
US Classification:
4242391
Abstract:
Methods for controlling abnormal blood flow in disease states by the selective alteration of the components of microvascular flow using Botulinum A Toxin, other SNARE protein mediating agents, alpha adrenergic agents, and other compounds is heretofore unknown, whether delivered by injection, topical application, or transdermal means. The invention discloses novel methods for the control of blood flow in skin, subcutaneous tissue and muscle by botulinum toxin, snare protein mediating substances, and alpha adrenergic agents by either injection or transdermal delivery systems.
Small-Scale Pressure Sensors
US Patent:
2010018, Jul 22, 2010
Filed:
Sep 28, 2007
Appl. No.:
12/443249
Inventors:
David L. Carroll - Winston-Salem NC, US
Faith M. Coldren - Strasbourg, FR
Nicole H. Levi - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US
William D. Wagner - Clemmons NC, US
Thomas L. Smith - Winston-Salem NC, US
Brian Werner - Lancaster PA, US
J. Baxter Mcguirt - Winston-Salem NC, US
Manoj Namboothiry - West Lafayette IN, US
Faith M. Coldren - Strasbourg, FR
Nicole H. Levi - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US
William D. Wagner - Clemmons NC, US
Thomas L. Smith - Winston-Salem NC, US
Brian Werner - Lancaster PA, US
J. Baxter Mcguirt - Winston-Salem NC, US
Manoj Namboothiry - West Lafayette IN, US
Assignee:
WAKE FOREST UNIVERSITY HEALTH SCIENCES - Winston-Salem NC
WAKE FOREST UNIVERSITY - Winston-Salem NC
WAKE FOREST UNIVERSITY - Winston-Salem NC
International Classification:
A61B 5/103
US Classification:
600587
Abstract:
The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.
Keratin Biomaterials For Treatment Of Ischemia
US Patent:
8545893, Oct 1, 2013
Filed:
Mar 8, 2011
Appl. No.:
13/043062
Inventors:
Mark E. Van Dyke - Winston-Salem NC, US
Thomas L. Smith - Winston-Salem NC, US
Michael Callahan - Winston-Salem NC, US
Luke Burnett - Winston-Salem NC, US
Thomas L. Smith - Winston-Salem NC, US
Michael Callahan - Winston-Salem NC, US
Luke Burnett - Winston-Salem NC, US
Assignee:
Wake Forest University Health Sciences - Winston-Salem NC
International Classification:
A61K 35/36
US Classification:
424543, 514 2192
Abstract:
Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
Keratin Biomaterials For Treatment Of Ischemia
US Patent:
2013034, Dec 26, 2013
Filed:
Aug 27, 2013
Appl. No.:
14/010902
Inventors:
Thomas L. Smith - Winston-Salem NC, US
Michael Callahan - Winston-Salem NC, US
Luke Burnett - Winston-Salem NC, US
Michael Callahan - Winston-Salem NC, US
Luke Burnett - Winston-Salem NC, US
Assignee:
Wake Forest University Health Sciences - Winston-Salem NC
International Classification:
A61K 38/17, A61K 38/48, A61K 31/727
US Classification:
424 9464, 514 212
Abstract:
Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
Controlled Delivery System
US Patent:
2011021, Sep 8, 2011
Filed:
Mar 7, 2011
Appl. No.:
13/042126
Inventors:
Mark E. Van Dyke - Winston-Salem NC, US
Justin M. Saul - Winston-Salem NC, US
Thomas L. Smith - Winston-Salem NC, US
Roche de Guzman - Winston-Salem NC, US
Justin M. Saul - Winston-Salem NC, US
Thomas L. Smith - Winston-Salem NC, US
Roche de Guzman - Winston-Salem NC, US
International Classification:
A61K 9/70, A61K 9/00, A61K 38/00, A61K 39/395, A61K 38/18, A61K 31/497
US Classification:
424443, 424484, 514 11, 4241301, 514 76, 51425308
Abstract:
Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest.