THOMAS JOSEPH SOWIN
Pilots at Reed Ct, Beach Park, IL
License number
Illinois A4778223
Issued Date
Jun 2015
Expiration Date
Jun 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
40338 Reed Ct, Beach Park, IL 60083
Professional information
Attached Tags For Use In Combinatorial Chemistry Synthesis
US Patent:
6355490, Mar 12, 2002
Filed:
Sep 4, 1997
Appl. No.:
08/923206
Inventors:
Jill Edie Hochlowski - Green Oaks IL 60048
Thomas J. Sowin - Wadsworth IL 60083
Daniel W. Norbeck - Crystal Lake IL 60012
Anne-Laure Marie Grillot - Cambridge IL 60093
Rolf E. Swenson - Grayslake IL 60030
Thomas J. Sowin - Wadsworth IL 60083
Daniel W. Norbeck - Crystal Lake IL 60012
Anne-Laure Marie Grillot - Cambridge IL 60093
Rolf E. Swenson - Grayslake IL 60030
International Classification:
G01N 33543
US Classification:
436518, 436527, 436528, 436531, 436 56, 530333, 530334, 530335, 558303, 558411, 558415, 558416, 558414, 558435, 558441
Abstract:
The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
Coding Combinatorial Libraries With Fluorine Tags
US Patent:
6168913, Jan 2, 2001
Filed:
Oct 14, 1997
Appl. No.:
8/949987
Inventors:
Jill Edie Hochlowski - Green Oaks IL
Thomas J. Sowin - Wadsworth IL
Daniel W. Norbeck - Crystal Lake IL
Warren S. Wade - Grayslake IL
David N. Whittern - Green Oaks IL
Thomas J. Sowin - Wadsworth IL
Daniel W. Norbeck - Crystal Lake IL
Warren S. Wade - Grayslake IL
David N. Whittern - Green Oaks IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C12Q 100, G01N 33566, G01N 33543
US Classification:
435 4
Abstract:
The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.
Attached Tags For Use In Combinatorial Chemistry Synthesis
US Patent:
6274385, Aug 14, 2001
Filed:
Aug 9, 1999
Appl. No.:
9/370437
Inventors:
Jill Edie Hochlowski - Green Oaks IL
Thomas J. Sowin - Wadsworth IL
Daniel W. Norbeck - Crystal Lake IL
Anne-Laure Marie Grillot - Winnetka IL
Rolf E. Swenson - Grayslake IL
Thomas J. Sowin - Wadsworth IL
Daniel W. Norbeck - Crystal Lake IL
Anne-Laure Marie Grillot - Winnetka IL
Rolf E. Swenson - Grayslake IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
G01N 33543, G01N 33552, C07C25500
US Classification:
436518
Abstract:
The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
Macrocyclic Kinase Inhibitors
US Patent:
7163939, Jan 16, 2007
Filed:
Nov 3, 2004
Appl. No.:
10/980740
Inventors:
Nan-Horng Lin - Vernon Hills IL, US
Gaoquan Li - Park City IL, US
Magdalena K. Przytulinska - Chicago IL, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Lake Villa IL, US
Zhi-Fu Tao - Gurnee IL, US
Yunsong Tong - Libertyville IL, US
Le Wang - Vernon Hills IL, US
Gaoquan Li - Park City IL, US
Magdalena K. Przytulinska - Chicago IL, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Lake Villa IL, US
Zhi-Fu Tao - Gurnee IL, US
Yunsong Tong - Libertyville IL, US
Le Wang - Vernon Hills IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 513/08, A61K 31/529
US Classification:
5142315, 514250, 540456
Abstract:
Compounds having the formula.
Fused Tri And Tetra-Cyclic Pyrazole Kinase Inhibitors
US Patent:
7320986, Jan 22, 2008
Filed:
Mar 3, 2004
Appl. No.:
10/792564
Inventors:
Yunsong Tong - Grayslake IL, US
Akiyo K. Claiborne - Mundelein IL, US
Gaoquan Li - Park City IL, US
Nan-Horng Lin - Vernon Hills IL, US
Hing L. Sham - Vernon Hills IL, US
Thomas J. Sowin - Wadsworth IL, US
Zhi-Fu Tao - Gurnee IL, US
Akiyo K. Claiborne - Mundelein IL, US
Gaoquan Li - Park City IL, US
Nan-Horng Lin - Vernon Hills IL, US
Hing L. Sham - Vernon Hills IL, US
Thomas J. Sowin - Wadsworth IL, US
Zhi-Fu Tao - Gurnee IL, US
Assignee:
Abbott Labortories - Abbott Park IL
International Classification:
A61K 31/4745, A61K 31/4162, C07D 487/14
US Classification:
514292, 514406, 546 82, 5483595
Abstract:
Compounds having the formula (I).
Cyclobut-3-Ene-1,2,-Dione Inhibitors Of Polo-Like Kinases
US Patent:
7956185, Jun 7, 2011
Filed:
May 24, 2007
Appl. No.:
11/753279
Inventors:
Robert B. Diebold - Waltham MA, US
Stevan W. Djuric - Libertyville IL, US
Vincent L. Giranda - Gurnee IL, US
Laura A. Hexamer - Grayslake IL, US
Nan-Horng Lin - Vernon Hills IL, US
Julie M. Miyashiro - Morton Grove IL, US
Thomas D. Penning - Elmhurst IL, US
Magdalena Przytulinska - Chicago IL, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Lake Villa IL, US
Zhi-Fu Tao - Gurnee IL, US
Yunsong Tong - Libertyville IL, US
Anil Vasudevan - Union Grove WI, US
Le Wang - Vernon Hills IL, US
Keith W. Woods - Libertyville IL, US
Zhiren Xia - Gurnee IL, US
Henry Q. Zhang - Grayslake IL, US
Stevan W. Djuric - Libertyville IL, US
Vincent L. Giranda - Gurnee IL, US
Laura A. Hexamer - Grayslake IL, US
Nan-Horng Lin - Vernon Hills IL, US
Julie M. Miyashiro - Morton Grove IL, US
Thomas D. Penning - Elmhurst IL, US
Magdalena Przytulinska - Chicago IL, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Lake Villa IL, US
Zhi-Fu Tao - Gurnee IL, US
Yunsong Tong - Libertyville IL, US
Anil Vasudevan - Union Grove WI, US
Le Wang - Vernon Hills IL, US
Keith W. Woods - Libertyville IL, US
Zhiren Xia - Gurnee IL, US
Henry Q. Zhang - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 239/02
US Classification:
544297, 544162, 544211, 544402, 546159, 546246, 5462681, 548127, 548128, 548161, 548202, 548235, 548257, 5482622, 5483074, 5483461, 5483621, 5483731, 548470, 548503, 548517, 549 49, 549 80, 549471, 585 23
Abstract:
Compounds of formula (I).
Heterocyclic Kinase Inhibitors
US Patent:
7456169, Nov 25, 2008
Filed:
Aug 23, 2006
Appl. No.:
11/466638
Inventors:
Lisa A. Hasvold - Grayslake IL, US
Laura Hexamer - Gurnee IL, US
Gaoquan Li - Madison WI, US
Nan-Horng Lin - Vernon Hills IL, US
Hing Sham - South San Francisco CA, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Labe Villa IL, US
Le Wang - Mundelein IL, US
Ping Xia - St. Louis MO, US
Laura Hexamer - Gurnee IL, US
Gaoquan Li - Madison WI, US
Nan-Horng Lin - Vernon Hills IL, US
Hing Sham - South San Francisco CA, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Labe Villa IL, US
Le Wang - Mundelein IL, US
Ping Xia - St. Louis MO, US
Assignee:
Abbott Laboratories Inc. - Abbott Park IL
International Classification:
C07D 413/00, A61K 31/5513
US Classification:
514220, 540495
Abstract:
Compounds having the formula.
Macrocyclic Kinase Inhibitors
US Patent:
2005009, May 5, 2005
Filed:
Nov 5, 2003
Appl. No.:
10/702140
Inventors:
Zhi-Fu Tao - Gurnee IL, US
Nan-Horng Lin - Vernon Hills IL, US
Le Wang - Vernon Hills IL, US
Thomas Sowin - Wadsworth IL, US
Nan-Horng Lin - Vernon Hills IL, US
Le Wang - Vernon Hills IL, US
Thomas Sowin - Wadsworth IL, US
International Classification:
A61K031/498, C07D491/14
US Classification:
514250000, 540456000, 540460000
Abstract:
Compounds having the formula
are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.