Inventors:
Thomas Roberts - Boston MA, US
Ole Gjoerup - Boston MA, US
Parmjit Jat - New York NY, US
International Classification:
A61K 48/00, A61P 25/16, A61P 25/28, C07H 21/04, C12N 5/08
US Classification:
424093210, 435183000, 435325000, 435366000, 530350000, 530403000, 536023100, 435368000
Abstract:
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.