THOMAS E WELLEMS
Medical Practice in Rockville, MD
License number
Pennsylvania MD028200E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Rockville, MD 20852
Pennsylvania
Pennsylvania
Personal information
See more information about THOMAS E WELLEMS at radaris.comName
Address
Phone
1715 Wilmart St, Rockville, MD 20852
1715 Wilmart St, Rockville, MD 20852
Professional information
Binding Domains From Plasmodium Vivax And Plasmodium Falciparum Erythrocyte Binding Proteins
US Patent:
6392026, May 21, 2002
Filed:
Dec 11, 1998
Appl. No.:
09/210288
Inventors:
Kim Lee Sim - Gaithersburg MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07H 2104
US Classification:
536 235, 514 44
Abstract:
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by or. In particular, the polypeptides are derived from the binding domains of the proteins in the EBL family as well as the sialic acid binding protein (SABP) on merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on merozoites.
Recombinant Dna Clone Containing A Genomic Fragment Of Pfhrp-Ii Gene From Plasmodium Falciparum
US Patent:
5476785, Dec 19, 1995
Filed:
Dec 6, 1993
Appl. No.:
8/161406
Inventors:
Thomas E. Wellems - Rockville MD
Russell J. Howard - Gaithersburg MD
Russell J. Howard - Gaithersburg MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
C12N 121, C12N 1530, C12N 1570, C07K 14445
US Classification:
4352523
Abstract:
The invention relates to isolated clones of DNA from Plasmodium falciparum that encode a histidine-rich protein from that organism. The PfHRPII protein is expressed in P. falciparum-infected erythrocytes. The cloned gene segment includes an intron-exon boundary near the amino-terminus of the coding sequence. The PfHRPII protein has a Mr of 60-80 kDa as determined by SDS-PAGE. This is substantially higher than the molecular weight of about 35 kDa as estimated from the predicted amino acid sequence of PfHRPII. The PfHRPII amino acid sequence includes a hydrophobic leader sequence, consistent with secretion of PfHRPII observed in vivo and in vivo. The amino acid sequence of PfHRPII is also characterized by a number of tandem repeats having a high content of histidine, alanine and aspartic acid.
Binding Domains From Plasmodium Vivax And Plasmodium Falciparum Erythrocyte Binding Proteins
US Patent:
6962987, Nov 8, 2005
Filed:
May 21, 2002
Appl. No.:
10/153273
Inventors:
Kim Lee Sim - Gaithersburg MD, US
Chetan Chitnis - Washington DC, US
Louis H. Miller - Bethesda MD, US
David S. Peterson - Rockville MD, US
Thomas E. Wellems - Rockville MD, US
Chetan Chitnis - Washington DC, US
Louis H. Miller - Bethesda MD, US
David S. Peterson - Rockville MD, US
Thomas E. Wellems - Rockville MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07H021/04
US Classification:
536 235
Abstract:
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by or. In particular, the polypeptides are derived from the binding domains of the proteins in the EBL family as well as the sialic acid binding protein (SABP) on merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on merozoites.
Binding Domains From Plasmodium Vivax And Plasmodium Falciparum Erythrocyte Binding Proteins
US Patent:
5849306, Dec 15, 1998
Filed:
Dec 7, 1995
Appl. No.:
8/568459
Inventors:
Kim Lee Sim - Gaithersburg MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
A61K 39015, C07K 14445
US Classification:
4242681
Abstract:
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by Plasmodium falciparum or P. vivax. In particular, the polypeptides are derived from the binding domains of the proteins in the EBL family as well as the sialic acid binding protein (SABP) on P. falciparum merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on P. vivax merozoites.
Recombinant Dna Clone Containing A Genomic Fragment Of Pfhrp-Ii Gene From Plasmodium Falciparum
US Patent:
5296382, Mar 22, 1994
Filed:
Nov 14, 1991
Appl. No.:
7/791392
Inventors:
Thomas E. Wellems - Rockville MD
Russell J. Howard - Gaithersburg MD
Russell J. Howard - Gaithersburg MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
G01N 33536, A61K 3516, C07K 1528
US Classification:
436501
Abstract:
The present invention resides, in part, in cloned DNA fragments encoding a histidine-rich protein of Plasmodium falciparum (PfHRP-II). PfHRP-II is a malarial antigen that is secreted by the parasite into erythrocytes. The protein is characterized by tandem repeats of high histidine, alanine and aspartate content. The protein is found to have high affinity for divalent cations. Cloning and characterization of the PfHRP-II gene are described, as are antibodies against PfHRP-II.
Binding Domains From Plasmodium Vivax And Plasmodium Falciparum Erythrocyte Binding Proteins
US Patent:
5993827, Nov 30, 1999
Filed:
Jun 7, 1995
Appl. No.:
8/487826
Inventors:
Kim Lee Sim - Gaithersburg MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Chetan Chitnis - Washington DC
Louis H. Miller - Bethesda MD
David S. Peterson - Rockville MD
Thomas E. Wellems - Rockville MD
Assignee:
The United States of America as represented by the Secretary, Department
of Health and Human Services - Washington DC
of Health and Human Services - Washington DC
International Classification:
A61K 39015, C12N 1530
US Classification:
4242681
Abstract:
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by Plasmodium falciparum or P. vivax. In particular, the polypeptides are derived from the binding domains of the proteins in the DBL family as well as the sialic acid binding protein (SABP) on P. falciparum merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on P. vivax merozoites.
Recombinant Dna Clone Containing A Genomic Fragment Of Pfhrp-Ii Gene From Plasmodium Falciparum
US Patent:
5130416, Jul 14, 1992
Filed:
May 3, 1990
Appl. No.:
7/518299
Inventors:
Thomas E. Wellems - Rockville MD
Russell J. Howard - Gaithersburg MD
Russell J. Howard - Gaithersburg MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
C07K 1300, C07K 1504, A61K 39015
US Classification:
530350
Abstract:
A histidine rich antigen, designated PfHRP-II, has been synthesized from a recombinant DNA clone containing a genomic fragment of Plasmodium falciparum. PfHRP-II is a protein exported from the parasite into the body fluid. This protein passes through the host erythrocyte in concentrated packets and is released from the infected erythrocyte into the body fluid. The antigen has been isolated and is useful for protection against malaria.