Inventors:
Thomas B. Nutman - Chevy Chase MD, US
David Abraham - Wynnewood PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
Health and Human Services - Bethesda MD
International Classification:
A61K 39/00, C07H 21/04, A61P 33/00, C07K 14/435
Abstract:
The polynucleotide encoding the SSIR gene from the nematode is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.