THOMAS A WILSON
Dietitian and Nutritionist in Haverhill, MA
License number
Massachusetts 1772
Issued Date
Jul 26, 2001
Expiration Date
Jul 22, 2005
Type
Nutritionist
Address
Address
Haverhill, MA 01835
Professional information
Compositions And Methods For Making And Using Nanoemulsions
US Patent:
2008027, Nov 6, 2008
Filed:
Jul 11, 2006
Appl. No.:
11/996016
Inventors:
Robert Nicolosi - Nashua NH, US
Thomas Wilson - Bradford MA, US
Thomas Wilson - Bradford MA, US
Assignee:
University of Massachusetts Lowell - Lowell MA
International Classification:
A61K 9/14, A61K 31/01, A01N 25/00, A61K 31/56, A61K 35/60, A61K 31/355, A61K 31/047, A61K 38/16, A01P 1/00
US Classification:
424489, 514169, 424555, 514458, 514729, 977906
Abstract:
The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased T, increased C, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes. Consequently, these nanoemulsions are expected to have a significantly prolonged shelf-life than currently available nanoemulsions.