Inventors:
Anton Wyss-Coray - Stanford CA, US
Thomas A. Rando - Stanford CA, US
Markus Britschgi - Allschwil, CH
Kaspar Rufibach - Bern, CH
Saul Abraham Villeda - Mountain View CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
DEPARTMENT OF VETERANS AFFAIRS - Washington DC
International Classification:
G01N 33/566, C12Q 1/68, C40B 30/04
US Classification:
506 9, 435 792, 435 71, 435 61
Abstract:
Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, 2-microglobulin, MCP-1 and Hap-toglobulin, increased expression of which has been shown to be associated with increase in biological aging process.