THERESA SHAPIRO, M.D.
Osteopathic Medicine at Wolfe St, Baltimore, MD
License number
Maryland D26744
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
600 N Wolfe St, Baltimore, MD 21287
Phone
(410) 955-9434
Personal information
See more information about THERESA SHAPIRO at radaris.comName
Address
Phone
1017 Hart Rd, Towson, MD 21286
1024 Hart Rd, Towson, MD 21286
150 Monroe St APT 101, Rockville, MD 20850
5901 Montrose Rd, Rockville, MD 20852
4858 Battery Ln, Bethesda, MD 20814
Organization information
See more information about THERESA SHAPIRO at bizstanding.comTheresa Shapiro MD,PHD
600 N Wolfe St, Baltimore, MD 21287
Industry:
Internist
Phone:
(410) 955-9434 (Phone)
Theresa Ann Shapiro
Professional information
Theresa Ann Shapiro, Baltimore MD
Specialties:
Internal Medicine, Cardiology, Clinical Pharmacology, General Practice
Work:
JHU Neurology
600 N Wolfe St, Baltimore, MD 21287
600 N Wolfe St, Baltimore, MD 21287
Education:
Johns Hopkins University (1976)
Dr. Theresa Shapiro, Baltimore MD - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
725 N Wolfe St, Baltimore 21205
(410) 955-1888 (Phone), (410) 955-2634 (Fax)
JOHNS HOPKINS SCH OF MED
725 N Wolfe St SUITE 301, Baltimore 21205
(410) 955-1888 (Phone)
(410) 955-1888 (Phone), (410) 955-2634 (Fax)
JOHNS HOPKINS SCH OF MED
725 N Wolfe St SUITE 301, Baltimore 21205
(410) 955-1888 (Phone)
Certifications:
Internal Medicine, 1981
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
725 N Wolfe St, Baltimore 21205
JOHNS HOPKINS SCH OF MED
725 N Wolfe St SUITE 301, Baltimore 21205
The Johns Hopkins Hospital
1800 Orleans St, Baltimore 21287
JOHNS HOPKINS SCH OF MED
725 N Wolfe St SUITE 301, Baltimore 21205
The Johns Hopkins Hospital
1800 Orleans St, Baltimore 21287
Education:
Medical School
Johns Hopkins University / School of Medicine
Graduated: 1976
Johns Hopkins University / School of Medicine
Graduated: 1976
Artemisinin Analogs Having Antimalarial, Antiproliferative, And Antitumor Activities And Chemoselective Methods Of Making The Same
US Patent:
6586464, Jul 1, 2003
Filed:
Jun 22, 2001
Appl. No.:
09/887922
Inventors:
Gary H. Posner - Baltimore MD
Hardwin ODowd - Somerville MA
Suji Xie - Baltimore MD
Theresa A. Shapiro - Towson MD
Christopher Murray - Longmont CO
Hardwin ODowd - Somerville MA
Suji Xie - Baltimore MD
Theresa A. Shapiro - Towson MD
Christopher Murray - Longmont CO
Assignee:
Johns Hopkins University - Baltimore MD
Hauser, Inc.
Hauser, Inc.
International Classification:
C07D51900
US Classification:
514450, 514365, 514367, 548203, 548179, 549348
Abstract:
Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is I and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
C-10 Carbon-Substituted Artemisinin-Like Trioxane Compounds Having Antimalarial, Antiproliferative And Antitumor Activities
US Patent:
6160004, Dec 12, 2000
Filed:
Oct 30, 1998
Appl. No.:
9/183693
Inventors:
Gary H. Posner - Baltimore MD
Soon Hyung Woo - Pointe-Claire, CA
Michael H. Parker - Baltimore MD
Theresa A. Shapiro - Towson MD
Jeffrey S. Elias - Baltimore MD
John Northrop - Baltimore MD
Qun Y. Zheng - Wayne NJ
Christopher Murray - Longmont CO
Randall J. Daughenbaugh - Longmont CO
Soon Hyung Woo - Pointe-Claire, CA
Michael H. Parker - Baltimore MD
Theresa A. Shapiro - Towson MD
Jeffrey S. Elias - Baltimore MD
John Northrop - Baltimore MD
Qun Y. Zheng - Wayne NJ
Christopher Murray - Longmont CO
Randall J. Daughenbaugh - Longmont CO
Assignee:
Hauser, Inc. - Boulder CO
Johns Hopkins University - Baltimore MD
Johns Hopkins University - Baltimore MD
International Classification:
A61K 31335, C07D49318
US Classification:
514450
Abstract:
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes; or when n is 3, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
C-10 Carbon-Substituted Artemisinin-Like Trioxane Compounds Having Antimalarial, Antiproliferative And Antitumor Activities
US Patent:
6156790, Dec 5, 2000
Filed:
Dec 30, 1997
Appl. No.:
9/001242
Inventors:
Gary H. Posner - Baltimore MD
Soon Hyung Woo - Pointe-Claire, CA
Michael H. Parker - Baltimore MD
Theresa A. Shapiro - Towson MD
Qun Y. Zheng - Wayne NJ
Christopher Murray - Longmont CO
Randall J. Daughenbaugh - Longmont CO
Soon Hyung Woo - Pointe-Claire, CA
Michael H. Parker - Baltimore MD
Theresa A. Shapiro - Towson MD
Qun Y. Zheng - Wayne NJ
Christopher Murray - Longmont CO
Randall J. Daughenbaugh - Longmont CO
Assignee:
Hauser, Inc. - Boulder CO
Johns Hopkins University - Baltimore MD
Johns Hopkins University - Baltimore MD
International Classification:
A61K 31335, C07D49318
US Classification:
514450
Abstract:
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
Orally Active, Antimalarial, Anticancer, Artemisinin-Derived Trioxane Dimers
US Patent:
7417156, Aug 26, 2008
Filed:
Sep 26, 2003
Appl. No.:
10/529513
Inventors:
Gary H. Posner - Baltimore MD, US
Theresa A. Shapiro - Towson MD, US
Surojit Sur - Baltimore MD, US
Tanzina Labonte - Baltimore MD, US
Kristina Borstnik - State College PA, US
Ik-Hyeon Paik - Baltimore MD, US
Andrew J. McRiner - Baltimore MD, US
Theresa A. Shapiro - Towson MD, US
Surojit Sur - Baltimore MD, US
Tanzina Labonte - Baltimore MD, US
Kristina Borstnik - State College PA, US
Ik-Hyeon Paik - Baltimore MD, US
Andrew J. McRiner - Baltimore MD, US
Assignee:
Johns Hopkins University - Baltimore MD
International Classification:
A61K 31/357, C07D 321/10
US Classification:
549348, 549 34, 549220, 548232, 514100, 514376, 514439, 514462, 514463
Abstract:
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and diol dimers (4 and 5) and ketone dimer (7) are 10 times more antimalarially potent in vitro than artemisinin (I), and alcohol and diol dimers (4 and 5) are strongly inhibitory but not cytotoxic toward several human cancer cell lines. Water-soluble carboxylic acid derivatives (8-10and 12) were easily prepared from dimers (4-6); they are thermally stable even at 60° C. for 24 hours, are more orally efficacious as antimalarials than either artelinic acid or sodium artesunate, and have potent and selective anticancer activities. Further derivitization of the alcohol dimers (4 and 17), diol dimer (5) and ketone (7) has produced a number of analogs also antimalarially active in vitro at sub-nanomolar concentrations (most notably: pyridine N-oxides (13, 15, 18, 23, 24 and 25), phosphoric acid triesters (26 and 27), sulfonamide (40) and cyclic carbonate (41)). In addition, dimers (13 and 19) are more efficacious (when administered both orally and i. v.
Artemisinin Analogs Having Antimalarial Antiproliferative And Antitumor Activities And Chemoselective Methods Of Making The Same
US Patent:
6297272, Oct 2, 2001
Filed:
Jan 12, 1999
Appl. No.:
9/228668
Inventors:
Gary H. Posner - Baltimore MD
Hardwin O'Dowd - Somerville MA
Suji Xie - Baltimore MD
Theresa A. Shapiro - Towson MD
Christopher Murray - Longmont CO
Hardwin O'Dowd - Somerville MA
Suji Xie - Baltimore MD
Theresa A. Shapiro - Towson MD
Christopher Murray - Longmont CO
Assignee:
Hauser, Inc. - Boulder CO
Johns Hopkins University - Baltimore MD
Johns Hopkins University - Baltimore MD
International Classification:
A61K 21357, C07D51900
US Classification:
514450
Abstract:
Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure ##STR1##
or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is 1 and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
Inhibition Of Hemoflagellates By Camptothecin Compounds
US Patent:
5496830, Mar 5, 1996
Filed:
Sep 14, 1994
Appl. No.:
8/305603
Inventors:
Theresa A. Shapiro - Towson MD
Annette L. Bodley - Elkton MD
Monroe E. Wall - Chapel Hill NC
Mansukh C. Wani - Durham NC
Annette L. Bodley - Elkton MD
Monroe E. Wall - Chapel Hill NC
Mansukh C. Wani - Durham NC
Assignee:
Johns Hopkins University - Baltimore MD
Research Triangle Institute - Research Triangle Park NC
Research Triangle Institute - Research Triangle Park NC
International Classification:
A61K 31395, A61K 3155, A61K 3154, A61K 31535
US Classification:
514283
Abstract:
Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.
Water-Soluble Trioxanes As Potent And Safe Antimalarial Agents
US Patent:
6136847, Oct 24, 2000
Filed:
Apr 7, 1999
Appl. No.:
9/287353
Inventors:
Gary H. Posner - Baltimore MD
Michael H. Parker - Baltimore MD
Mikhail Krasavin - Baltimore MD
Theresa A. Shapiro - Baltimore MD
Michael H. Parker - Baltimore MD
Mikhail Krasavin - Baltimore MD
Theresa A. Shapiro - Baltimore MD
Assignee:
Johns Hopkins University - Baltimore MD
International Classification:
A61K 31335, A61K 31357, A61P 3306, C07D32306
US Classification:
514450
Abstract:
Biologically-active, water soluble, 3-substituted trioxanes of the formula ##STR1## wherein R represents a COOH-- substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl group, and C. sub. 12 -(p-carboxy)benzyloxy trioxanes of formula ##STR2## wherein R represents a substituted or unsubstituted alkyl, alkenyl, aryl or heteroaryl group and methods for their use as antiparasitic agents, particularly for the treatment of malaria.