Inventors:
Christopher Reading - San Diego CA, US
Clarence Ahlem - San Diego CA, US
Dominick Auci - San Diego CA, US
Charles Dowding - San Diego CA, US
James Frincke - San Diego CA, US
Mei Li - San Diego CA, US
Theodore Page - Carlsbad CA, US
Dwight Stickney - Granite Bay CA, US
Richard Trauger - Leucadia CA, US
Steven White - San Diego CA, US
International Classification:
A61K031/57
Abstract:
The invention relates to the use of compounds to ameliorate or treat a condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3β-hydroxy-17β-aminoandrost-5-ene, 3β-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3α-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3β-hydroxy-16β-fluoro-17β-aminoandrost-5-ene, 1α,3β-dihydroxy-4α-fluoroandrost-5-ene-17-one, 1α,3β,17β-trihydroxy-4α-fluoroandrost-5-ene, 1β,3β-dihydroxy-6α-bromoandrost-5-ene, 1α-fluoro-3β,12α-dihydroxyandrost-5-ene-17-one, 1α-fluoro-3β,4α-dihydroxyandrost-5-ene and 4α-fluoro-3β,6α,17β-trihydroxyandrostane.