Inventors:
Steven R. Brant - Reisterstown MD, US
Amir Karban - Baltimore MD, US
Franklin Nouvet - Severn MD, US
Theodore M. Bayless - Baltimore MD, US
James J. Potter - Baltimore MD, US
Esteban Mezey - Baltimore MD, US
Toshihiko Okazaki - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 38/17, A61P 29/00, C07K 14/435, C07H 21/04, C12Q 1/68, G01N 33/566
US Classification:
514 11, 435 611, 436501, 530350, 536 241, 536 243
Abstract:
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining similar relationships between specific pathologies and identified polymorphisms. A statistically significant risk of developing ulcerative colitis was shown to be correlated with the presence of an ATTG insertion/deletion in the NFKB1 promoter and is likely to apply also to a variety of other inflammatory diseases.