DR. THEODOR KOLOBOW, M.D.
Osteopathic Medicine at Hounds Way, Rockville, MD

5722395, Mar 3, 1998

May 14, 1996

8/645887

Theodor Kolobow - Rockville MD

The United States of America as represented by the Department of Health
and Human Services - Washington DC

A61M 1604

12820714

An ultra thin walled wire reinforced endotracheal tubing includes a thin walled tubing comprising a polymeric material having a spring material incorporated therewith. Utilization of the spring wire material in combination with polymeric material results in a reduced wall thickness which results in a significant decrease in resistance to air flow through the endotracheal tubing. The endotracheal tubing of the present invention is made by depositing a dissolvable polymeric material on a rotating mandrel in successive layers. A spring material is also applied around the mandrel to produce the ultra thin walled wire reinforced endotracheal tubing. By controlling the rate of deposition of polymeric material along the length of the mandrel, different wall thicknesses of tubing may be achieved.

5687714, Nov 18, 1997

Oct 10, 1995

8/541846

Theodor Kolobow - Rockville MD

The United States of America as represented by the Department of Health
and Human Services - Washington DC

A61M 1600

12820714

An endotracheal tube apparatus (10) which can efficiently impart air to the lungs of a human or animal while preventing the harmful build up of mucus deposits on critical parts of the apparatus. This endotracheal tube apparatus features an endotracheal tube (12) and a catheter (14) which are together inserted into the trachea (16) of a human or animal to a point slightly above the carina (28) of the lungs. Humidified air entrained with water or saline droplets from reservoir (56) is pumped into and through the catheter. The catheter features a reverse thrust catheter (RTC) tip (60, 62, 64, 80) at its distal end (24) which reverses the direction of humidified air flow away from the lungs. The RTC tip serves to protect the lungs from accumulation of water or saline droplets while the water or saline droplets continually clean both the catheter and endotracheal tube by dissolving and expelling any mucus which might otherwise accumulate.

5537729, Jul 23, 1996

Mar 2, 1993

8/026231

Theodor Kolobow - Rockville MD

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

A61M 1604

295272

An ultra thin walled wire reinforced endotracheal tubing includes a thin walled tubing comprising a polymeric material having a spring material incorporated therewith. Utilization of the spring wire material in combination with polymeric material results in a reduced wall thickness which results in a significant decrease in resistance to air flow through the endotracheal tubing. The endotracheal tubing of the present invention is made by depositing a dissolvable polymeric material on a rotating mandrel in. successive layers. A spring material is also applied around the mandrel to produce the ultra thin walled wire reinforced endotracheal tubing. By controlling the rate of deposition of polymeric material along the length of the mandrel, different wall thicknesses of tubing may be achieved.

5255675, Oct 26, 1993

Oct 31, 1990

7/606967

Theodor Kolobow - Rockville MD

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

A61M 1600, A62B 700, A62B 906, F15C 108

12820418

A method and apparatus for intratracheal ventilation (ITV) and intratracheal pulmonary ventilation (ITPV) in which a catheter positioned in a patient's trachea at the carina supplies a constant supply of fresh oxygen containing gas to flush anatomical dead space. By positioning the catheter in the patient's trachea, the dead space of the trachea is bypassed and the trachea is only utilized for expiration. By providing a timed expiratory valve in the ITPV mode, lower pressures and fresh oxygen flow rates may be utilized with respiratory rates from 10 to 120 breaths per minute or higher. The catheter has a diffuser tip, and the patient is ventilated at a flow rate between 0. 54 to 4 times the anatomical dead space per breath.

7503328, Mar 17, 2009

Mar 15, 2005

11/081420

Theodor Kolobow - Rockville MD, US
Gianluigi Li Bassi - Bethesda MD, US
Francesco Curto - Bethesda MD, US

The United States of America as represented by the Secretary of The Department of Health and Human Services - Washington DC

A61M 16/00, A62B 9/06

12820714, 12820026, 12820715, 12820716, 604 9301

An endotracheal tube assembly () is disclosed which suctions away bacteria multiplying mucus before such mucus can accumulate on the inside walls of the endotracheal tube (). In the preferred embodiment, one or more suctioning tubes () are formed into the walls of an endotracheal tube so that they extend along length of the endotracheal tube. A plurality of mucus slurping holes () are then formed at or near the distal end of the endotracheal tube and connected to the suctioning tubes. In operation, suctioning through the mucus slurping holes is preferably performed intermittently during patient expiration. By timing this intermittent suctioning with patient expiration, the suctioning flow will be in the same direction as patient breathing. While the mucus slurper of the present invention has been found to be effective at keeping the inner walls of the endotracheal tube free of mucus deposits, it can nonetheless be combined with other cleaning and disinfectant techniques for greater assurance of cleanliness.

7107991, Sep 19, 2006

Sep 28, 2001

09/967903

Theodor Kolobow - Rockville MD, US

The United States of America as represented by the Department of Health & Human Services - Washington DC

A61M 16/00, A62B 9/06

12820714, 12820629

A tracheal tube ventilation apparatus to more effectively remove expired gases. In one preferred embodiment, one or more leak holes are created in the side walls of an endotracheal tube so that expired gases can leak out of the endotracheal tube above the larynx, such as into the back of the mouth (i. e. , oropharynx). Each leak hole might advantageously have a diameter between 0. 5 and 4. 0 mm. In another preferred embodiment, a tube is attached to a proportionately larger leak hole (e. g. , up to 8. 0 mm) so that the expired gases can be directed away from the leak hole to a specific location, such as directed out of the mouth. In the case of mechanically controlled ventilation, a positive end expiratory pressure can be applied to this tube to mechanically assist with the process of exhaling. In each of these embodiments, it is preferred, but not required, that the endotracheal tube be an ultra-thin walled, two stage tube so as to further assist in the reduction of resistance to the flow of oxygen/air.

4093515, Jun 6, 1978

Mar 1, 1976

5/663127

Theodor Kolobow - Rockville MD

Government of the United States - Washington DC

B01D 1300

195 18

A blood-compatible gas-permeable laminated carbon-containing silicone rubber membrane for use in a membrane artificial lung. The membrane is composed of at least two layers wherein the first layer is of silicone rubber compounded with silica filler and the second layer is of silicone rubber compounded with carbon black filler. The second layer may be sandwiched between the first layer and a third layer of either silicone rubber compounded with silica filler or filler-free silicone rubber. Utilizing such membrane for extracorporeal blood gas exchange in a membrane artifical lung results in elimination of thrombosis without the necessity for maintenance anticoagulant treatment during perfursion, and enables elimination of leukopenia and granulocytopenia or inhibition of blood platelet count decreases during perfusion.

5711296, Jan 27, 1998

Apr 22, 1994

8/231718

Theodor Kolobow - Rockville MD

The United States of America as represented by the Department of Health
and Human Services - Washington DC

A61M 1608

12820513

A passive continuous positive airway intratracheal pulmonary ventilation system which includes an inspiration limb and an expiration limb which are pressure balanced by inflatable bags. An intratracheal pulmonary ventilation system is provided which includes a catheter having a tip which is positioned through a low resistance endotracheal tube at or near a patient's carina. A constant source of an oxygen-containing gas flows through the catheter. The catheter has a tip which deflects and reverses the flow direction of the oxygen-containing gas.

7051737, May 30, 2006

Feb 5, 2004

10/773570

Theodor Kolobow - Rockville MD, US
Lorenzo Berra - San Giacomo, IT

The United States of America as represented by the Department of Health and Human Sevices - Washington DC

A61M 16/00

12820714, 12820026

An endotracheal tube cleaning apparatus which can be periodically inserted into the inside of an endotracheal tube to shave away mucus deposits. In a preferred embodiment, this cleaning apparatus comprises a flexible central tube with an inflatable balloon at its distal end. Affixed to the inflatable balloon are one or more shaving rings , each having a squared leading edge , to shave away mucus accumulations. In operation, the uninflated cleaning apparatus is inserted into the endotracheal tube. The balloon is then inflated by a suitable inflation device, such as a syringe , until the balloon's shaving rings are pressed against the inside surface of the endotracheal tube. The cleaning apparatus is then pulled out of the endotracheal tube to shave off mucus deposits.

3969240, Jul 13, 1976

Feb 3, 1975

5/546786

Theodor Kolobow - Rockville MD
Fusakazu Hayano - Tokyo, JA
Paul Weathersby - Rockville MD

The United States of America as represented by the Department of Health,
Education and Welfare - Washington DC

B01D 3100, B01D 1300

210 22A

A polydimethylsiloxane gum without silica filler is applied to silicone rubber membranes for use in a membrane lung.