Inventors:
The Methodist Hospital Research Institute - Houston TX, US
Ismail Mustafa Meraz - Pearland TX, US
Jianhua Gu - Houston TX, US
Xiaojun Xia - Houston TX, US
Haifa Shen - Bellaire TX, US
Tong Sun - Houston TX, US
Mauro Ferrari - Houston TX, US
Assignee:
The Methodist Hospital Research Institute - Houston TX
International Classification:
A61K 9/14, A61K 39/00
Abstract:
Disclosed are mesoporous silicon multi-stage vehicles that comprise liposomal-based second-stage particles, as well as pharmaceutical compositions and formulations including such vectors for use in a variety of diagnostic and therapeutic indications. In particular embodiments, MSV comprising ligand decorated second-stage particles are provided for therapeutic methods including, for example, treatment of mammalian cancers, including those of the human breast.