Inventors:
Partha Sarkar - League City TX, US
Tetsuo Ashizawa - Gainesville FL, US
Weidong XU - San Diego, CA, US
International Classification:
A61K 39/395, A61K 31/713, A61K 38/02, A61K 31/7088, A61P 21/00, G01N 33/566
US Classification:
4241721, 4241301, 514 44 A, 514 11, 514 44 R, 436501
Abstract:
The present invention concerns the methods and compositions involving nucleic acids with long repeat sequences. In some embodiments of the invention, there are methods for generating such a nucleic acid, and in other methods, there are methods for using such a nucleic acid to screen for candidate therapeutic compounds. Furthermore the present invention relates to methods of screening for Notch inhibitors and other substances that may be used to treat muscle loss and wasting.